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1,5-Dinitronaphthalene
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1,5-Dinitronaphthalene
Artikel-Nr:
(BOSSBS-3732R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3732R-FITC
Lokale Artikelnummer::
BOSSBS-3732R-FITC
Beschreibung:
The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor , gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3055R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3055R-A750
Lokale Artikelnummer::
BOSSBS-3055R-A750
Beschreibung:
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilisation, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defence. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3484R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3484R-A750
Lokale Artikelnummer::
BOSSBS-3484R-A750
Beschreibung:
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colourectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3938R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3938R-A750
Lokale Artikelnummer::
BOSSBS-3938R-A750
Beschreibung:
Defects in FH are the cause of fumarase deficiency (FHD)also known as fumaricaciduria. FHD is characterised by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7000R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7000R-A750
Lokale Artikelnummer::
BOSSBS-7000R-A750
Beschreibung:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0990R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0990R
Lokale Artikelnummer::
BOSSBS-0990R
Beschreibung:
Anti-HPV16 E6 protein Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5371R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5371R-CY5
Lokale Artikelnummer::
BOSSBS-5371R-CY5
Beschreibung:
PMVK is a 192 amino acid peroxisomal enzyme belonging to the nucleoside monophosphate (NMP) kinase family and is expressed in heart, liver, skeletal muscle, kidney, and pancreas with lower expression in brain, placenta and lung. Induced by sterol, PMVK participates in isopentenyl diphosphate biosynthesis via the mevalonate pathway. PMVK catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway. PMVK exists as a monomer and is encoded by a gene located on human chromosome 1, which houses over 3,000 genes and is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8876R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8876R-A680
Lokale Artikelnummer::
BOSSBS-8876R-A680
Beschreibung:
Flagellin is the subunit protein which polymerises to form the filaments of bacterial flagella. FlaB/D is not essential for polar flagellar synthesis and swimming motility. Homopolymer of FlaB/D is not able to form a functional filament.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8217R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8217R-CY3
Lokale Artikelnummer::
BOSSBS-8217R-CY3
Beschreibung:
FAM59B
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3949R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3949R-CY5.5
Lokale Artikelnummer::
BOSSBS-3949R-CY5.5
Beschreibung:
Members of the STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13215R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13215R-A647
Lokale Artikelnummer::
BOSSBS-13215R-A647
Beschreibung:
This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6220R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6220R-A488
Lokale Artikelnummer::
BOSSBS-6220R-A488
Beschreibung:
The TRIM motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7417R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7417R-FITC
Lokale Artikelnummer::
BOSSBS-7417R-FITC
Beschreibung:
SAP 155 is a 1,304 amino acid member of the SF3B1 family and contains eleven HEAT repeats. Localized to nuclear speckles and also to the cytoplasm during mitosis, SAP 155 is a subunit of the SF3B splicing factor. The SF3B splicing factor is a U2 snRNP-associated protein complex essential for spliceosome assembly. SF3B contains the spliceosomal proteins SAP 49, SAP 130, SAP 145 and SAP 155. Concomitant with splicing catalysis, SAP 155 is phosphorylated at its N-terminal Thr-Pro dipeptide motifs by Dyrk1A and cyclin E/Cdk2. This modification of SAP 155 is vital for a functional spliceosome as it is an essential event in the basic splicing reaction. Due to alternative splicing events, various SAP 155 isoforms are produced.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5904R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5904R-A750
Lokale Artikelnummer::
BOSSBS-5904R-A750
Beschreibung:
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3942R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3942R-A555
Lokale Artikelnummer::
BOSSBS-3942R-A555
Beschreibung:
GNB2 belongs to the WD repeat G protein beta family. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7786R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7786R-FITC
Lokale Artikelnummer::
BOSSBS-7786R-FITC
Beschreibung:
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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