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(±)-2-Phenyl-1-propanol
Artikel-Nr:
(PRSI79-235)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-235
Lokale Artikelnummer::
PRSI79-235
Beschreibung:
Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5637)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5637
Lokale Artikelnummer::
PRSI5637
Beschreibung:
DCLK3 Antibody: DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4853)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4853
Lokale Artikelnummer::
PRSI4853
Beschreibung:
Aipl1 Antibody: Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI46-247)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
46-247
Lokale Artikelnummer::
PRSI46-247
Beschreibung:
Anti-PTF1A Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI30-487)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-487
Lokale Artikelnummer::
PRSI30-487
Beschreibung:
Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon¡¡lysine crosslinks. Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).
VE:
1 * 50 µG
Artikel-Nr:
(PRSI24-231)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
24-231
Lokale Artikelnummer::
PRSI24-231
Beschreibung:
Anti-TYRP1 Recombinant Antibody [Clone: TA99]
VE:
1 * 0,2 mg
New Product
Artikel-Nr:
(PRSI24-407)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
24-407
Lokale Artikelnummer::
PRSI24-407
Beschreibung:
Anti-Ley Recombinant Antibody [Clone: BR96]
VE:
1 * 0,2 mg
New Product
Artikel-Nr:
(PRSI24-807)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
24-807
Lokale Artikelnummer::
PRSI24-807
Beschreibung:
Anti-S Recombinant Antibody [Clone: CR3022]
VE:
1 * 0,05 mg
New Product
Artikel-Nr:
(PRSI33-502)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-502
Lokale Artikelnummer::
PRSI33-502
Beschreibung:
CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. [UniProt].
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI25-419)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-419
Lokale Artikelnummer::
PRSI25-419
Beschreibung:
SPI1 is known to collaborate with multiple transcription factors and to regulate expression of immunoglobulin genes. Lack of SPI1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI28-941)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-941
Lokale Artikelnummer::
PRSI28-941
Beschreibung:
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually
VE:
1 * 50 µG
Artikel-Nr:
(PRSI29-985)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-985
Lokale Artikelnummer::
PRSI29-985
Beschreibung:
POR is an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this POR gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI42-314)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
42-314
Lokale Artikelnummer::
PRSI42-314
Beschreibung:
Anti-BBS1 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI96-027)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-027
Lokale Artikelnummer::
PRSI96-027
Beschreibung:
Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI22-467)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
22-467
Lokale Artikelnummer::
PRSI22-467
Beschreibung:
Anti-TAF1C Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI76-213)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-213
Lokale Artikelnummer::
PRSI76-213
Beschreibung:
The Hit3a monoclonal antibody specifically reacts with the Epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.The HIT3a antibody cross-links with the TCR complex, initiating the cellular activation and proliferation, but it cannot be used for intracellular CD3 staining, as it is able to stain only the surface CD3 complex.
VE:
1 * 0,1 mg
New Product
Preis auf Anfrage
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noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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