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5-Brom-2-fluor-4-nitrotoluol
Artikel-Nr:
(BOSSBS-3614R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3614R-A555
Lokale Artikelnummer::
BOSSBS-3614R-A555
Beschreibung:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0444R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0444R-A750
Lokale Artikelnummer::
BOSSBS-0444R-A750
Beschreibung:
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalisation of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalisation of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11024R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11024R-A555
Lokale Artikelnummer::
BOSSBS-11024R-A555
Beschreibung:
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13328R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13328R-A555
Lokale Artikelnummer::
BOSSBS-13328R-A555
Beschreibung:
Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA). The human Gemin4 maps to chromosome 17p13.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5514R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5514R-A488
Lokale Artikelnummer::
BOSSBS-5514R-A488
Beschreibung:
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3795R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3795R-A350
Lokale Artikelnummer::
BOSSBS-3795R-A350
Beschreibung:
Gross cystic disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15 kDa monomer protein, GCDFP 15. The cells within the body that produce GCDFP 15 appear to be restricted primarily to those with apocrine function. Studies have found GCDFP 15 to be a highly specific and sensitive marker for breast cancer.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5290R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5290R-A488
Lokale Artikelnummer::
BOSSBS-5290R-A488
Beschreibung:
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8618R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8618R-A647
Lokale Artikelnummer::
BOSSBS-8618R-A647
Beschreibung:
The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7921R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7921R-A647
Lokale Artikelnummer::
BOSSBS-7921R-A647
Beschreibung:
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.Involvement in disease:Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2) . VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1658R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1658R-A647
Lokale Artikelnummer::
BOSSBS-1658R-A647
Beschreibung:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7525R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7525R-A350
Lokale Artikelnummer::
BOSSBS-7525R-A350
Beschreibung:
This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12133R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12133R-A350
Lokale Artikelnummer::
BOSSBS-12133R-A350
Beschreibung:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5444R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5444R-A488
Lokale Artikelnummer::
BOSSBS-5444R-A488
Beschreibung:
The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells; its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6234R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6234R-A350
Lokale Artikelnummer::
BOSSBS-6234R-A350
Beschreibung:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl functionDOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function. There are 4 isoforms generated by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12261R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12261R-A350
Lokale Artikelnummer::
BOSSBS-12261R-A350
Beschreibung:
RTF1 is the the major histocompatibility complex (MHC) in the rat which contains genes that code for two class II histocompatibility antigens. RT1-B is an antigen of the RT1 complex. It is a protein dimer consisting of an alpha and beta glycoprotein chain and is homologous to I-A and I-E genes, respectively, in the H-2 complex of the mouse. MHC Class II antigens are useful in studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these also stain stromal cells in the thymus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10427R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10427R-A750
Lokale Artikelnummer::
BOSSBS-10427R-A750
Beschreibung:
Synaptobrevins/VAMPs, syntaxins, and the 25 kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localisation, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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