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(2S)-2-(4-Bromophenyl)-2-hydroxyacetic+acid
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(2S)-2-(4-Bromophenyl)-2-hydroxyacetic+acid
Lieferant:
COMBI-BLOCKS
Beschreibung:
4-(Boc-amino)cyclohexanon
Artikel-Nr:
(BOSSBS-10994R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10994R-FITC
Lokale Artikelnummer::
BOSSBS-10994R-FITC
Beschreibung:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent on C1D.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10994R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10994R-A680
Lokale Artikelnummer::
BOSSBS-10994R-A680
Beschreibung:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localisation of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent on C1D.
VE:
1 * 100 µl
Artikel-Nr:
(ERGODVA421W-VERT)
Lieferant:
ERGOMAT
Hersteller-Artikelnummer::
DVA421W-VERT
Lokale Artikelnummer::
ERGODVA421W-VERT
Beschreibung:
DuraView's attention grabbing yellow border protects US letter and A4 sized paper inserts on three sides for easy exchange flexibility.
VE:
1 * 10 ST
Lieferant:
MOLDEX
Beschreibung:
Earplugs made from soft PU-foam for protection against lower noise levels.
Lieferant:
UVEX
Beschreibung:
These disposable overalls are made of a very light, microporous PE laminate, combined with an SMS back section for high breathability. The overalls guarantee a high level of protection against liquid splashes and solid particles.
Lieferant:
FLUOROCHEM
Beschreibung:
2-Methyl-2-propanyl-(trans-4-hydroxycyclohexyl)carbamat
Artikel-Nr:
(630-9281)
Lieferant:
KARTELL
Hersteller-Artikelnummer::
216
Lokale Artikelnummer::
KART216
Beschreibung:
Clear acrylic resin microscope cover protects against dust and dirt.
VE:
1 * 1 ST
Lieferant:
ABCR
Beschreibung:
2-Methyl-2-propanyl-(trans-4-hydroxycyclohexyl)carbamat
Lieferant:
VICI JOUR RESEARCH
Beschreibung:
These safety exhaust filters can be placed on the waste bottle of an HPLC system, to protect workers from solvent vapors in the ambient air.
Lieferant:
ANSELL HEALTH CARE
Beschreibung:
Innovative, mehrschichtige Technologie für den Chemikalienschutz, Schutz der Typen 3/4/5.
Lieferant:
TQC
Beschreibung:
Handy, fast and robust coating thickness gauges used in the automobile industries for precise measurements of lacquer and corrosion protection.
Lieferant:
Portwest Clothing
Beschreibung:
This stylish shirt is lightweight and comfortable. Maximum protection is guaranteed with permanent flame resistance and ARC2 protection against electric arc.
Lieferant:
Biotium
Beschreibung:
This antibody neutralises HurTNFamediated cytotoxicity of L929 cells and inhibits tumour growth in mice. It protects mice against toxicity of HurTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.
Artikel-Nr:
(BOSSBS-20252R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-20252R-A680
Lokale Artikelnummer::
BOSSBS-20252R-A680
Beschreibung:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1335R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1335R-A647
Lokale Artikelnummer::
BOSSBS-1335R-A647
Beschreibung:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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