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5-Fluor-2-benzo[b]thiophencarbonsäure
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5-Fluor-2-benzo[b]thiophencarbonsäure
Artikel-Nr:
(BOSSBS-11716R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11716R-A555
Lokale Artikelnummer::
BOSSBS-11716R-A555
Beschreibung:
CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3990R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3990R-A647
Lokale Artikelnummer::
BOSSBS-3990R-A647
Beschreibung:
This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4081R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4081R-A488
Lokale Artikelnummer::
BOSSBS-4081R-A488
Beschreibung:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3680R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3680R-A647
Lokale Artikelnummer::
BOSSBS-3680R-A647
Beschreibung:
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12040R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12040R-A488
Lokale Artikelnummer::
BOSSBS-12040R-A488
Beschreibung:
alpha2C-adrenergic receptors (alpha2C-AR) regulate neurotransmitter release from sympathetic nerves in the heart, and from adrenergic neurons in the central nervous system. alpha2C-AR can influence Parkinson’s disease, panic disorders, and Huntington disease (HD) progression. A genetic variant in the alpha2C-AR coding region (Del322-325) renders the receptor partially uncoupled from Gi, and is a contributing risk factor for heart failure. alpha2C-AR transcripts are present in rat muscle, heart, pancreas, and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5491R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5491R-A350
Lokale Artikelnummer::
BOSSBS-5491R-A350
Beschreibung:
MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) belongs to the serine/threonine protein kinase family and specifically activates MAPK8/JNK. It may play a role in the response to environmental stress and is thought to function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF alpha signaling pathway. It interacts with the SH3 domain of the adapter protein Nck. MAP4K4-dependent signaling inhibits PPARG responsive gene expression, adipogenesis, and insulin stimulated glucose transport.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13283R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13283R-A680
Lokale Artikelnummer::
BOSSBS-13283R-A680
Beschreibung:
GAPVD1 is a 1478 amino acid peripheral membrane protein that acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF). GAPVD1 participates in many processes such as insulin receptor internalization, Glut4 trafficking and endocytosis. In addition, depletion of GAPVD1 leads to delayed EGFR degradation by mediating receptor ubiquination through its RGD domain, suggesting that it may be an important mediator of carcinogenesis resulting from Ras protein mutations. There are six isoforms of GAPVD1 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11629R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11629R-A750
Lokale Artikelnummer::
BOSSBS-11629R-A750
Beschreibung:
Olfactory receptors are G protein-coupled receptors that localize to the cilia of olfactory sensory neurons where they display affinity for and bind to a variety of odor molecules. The genes encoding olfactory receptors comprise the largest family in the human genome. The binding of olfactory receptor proteins to odor molecules triggers a signal transduction that propagates nerve impulses throughout the body, ultimately leading to transmission of the signal to the brain and the subsequent perception of smell. OR10J3 (olfactory receptor 10J3) is a 329 amino acid protein. The gene encoding OR10J3 maps to human chromosome 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0444R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0444R-A350
Lokale Artikelnummer::
BOSSBS-0444R-A350
Beschreibung:
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10100R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10100R-A647
Lokale Artikelnummer::
BOSSBS-10100R-A647
Beschreibung:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3614R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3614R-A555
Lokale Artikelnummer::
BOSSBS-3614R-A555
Beschreibung:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0444R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0444R-A750
Lokale Artikelnummer::
BOSSBS-0444R-A750
Beschreibung:
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalisation of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalisation of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11024R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11024R-A555
Lokale Artikelnummer::
BOSSBS-11024R-A555
Beschreibung:
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13328R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13328R-A555
Lokale Artikelnummer::
BOSSBS-13328R-A555
Beschreibung:
Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA). The human Gemin4 maps to chromosome 17p13.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5514R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5514R-A488
Lokale Artikelnummer::
BOSSBS-5514R-A488
Beschreibung:
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3795R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3795R-A350
Lokale Artikelnummer::
BOSSBS-3795R-A350
Beschreibung:
Gross cystic disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15 kDa monomer protein, GCDFP 15. The cells within the body that produce GCDFP 15 appear to be restricted primarily to those with apocrine function. Studies have found GCDFP 15 to be a highly specific and sensitive marker for breast cancer.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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