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35 854 results were found
2-Amino-5-chloropyrazine
Artikel-Nr:
(BOSSBS-2903R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2903R
Lokale Artikelnummer::
BOSSBS-2903R
Beschreibung:
ARHI contains a highly conserved GTP-binding domain, a putative effector domain distinct from that of RAS and RAP proteins, and a C-terminal membrane localization motif. ARHI mRNA is detected in all normal breast and ovarian epithelial cell cultures tested, as well as in normal ovary, heart, liver, pancreas and brain however ARHI expression is down-regulated in breast and ovarian tumors. Reactivation of ARHI expression in breast cancer cells is associated with increased histone H3 acetylation and decreased lysine 9 methylation of histone H3.
VE:
1 * 100 µl
Artikel-Nr:
(SPCMA2107-200LTBL)
Lieferant:
Spectrum Chemical
Hersteller-Artikelnummer::
A2107-200LTBL
Lokale Artikelnummer::
SPCMA2107-200LTBL
Beschreibung:
α-Acetyl-γ-butyrolactone
VE:
1 * 200 L
Artikel-Nr:
(BOSSBS-3423R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3423R-A680
Lokale Artikelnummer::
BOSSBS-3423R-A680
Beschreibung:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3423R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3423R-A647
Lokale Artikelnummer::
BOSSBS-3423R-A647
Beschreibung:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8450R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8450R-A750
Lokale Artikelnummer::
BOSSBS-8450R-A750
Beschreibung:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 <i>in vitro</i>; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5272R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5272R-A680
Lokale Artikelnummer::
BOSSBS-5272R-A680
Beschreibung:
MRG15 ia a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5272R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5272R-A647
Lokale Artikelnummer::
BOSSBS-5272R-A647
Beschreibung:
MRG15 ia a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair.
VE:
1 * 100 µl
Artikel-Nr:
(38800-25MG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
38800-25MG
Lokale Artikelnummer::
SUPL38800-25MG
Beschreibung:
Malachitgrün-Chlorid, Supelco®
VE:
1 * 25 mg
Lieferant:
FLUOROCHEM
Beschreibung:
2-Acetyl-5-bromthiophen
Artikel-Nr:
(BOSSBS-1982R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1982R
Lokale Artikelnummer::
BOSSBS-1982R
Beschreibung:
MCM3 is one of the highly conserved mini-chromosome maintenance proteins that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11018R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11018R-A647
Lokale Artikelnummer::
BOSSBS-11018R-A647
Beschreibung:
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11018R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11018R-A488
Lokale Artikelnummer::
BOSSBS-11018R-A488
Beschreibung:
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13452R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13452R-A647
Lokale Artikelnummer::
BOSSBS-13452R-A647
Beschreibung:
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13452R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13452R-CY7
Lokale Artikelnummer::
BOSSBS-13452R-CY7
Beschreibung:
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2987R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2987R-A350
Lokale Artikelnummer::
BOSSBS-2987R-A350
Beschreibung:
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2987R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2987R-CY7
Lokale Artikelnummer::
BOSSBS-2987R-CY7
Beschreibung:
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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