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N-tert-Butyl-2-methylenesuccinamic+acid
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N-tert-Butyl-2-methylenesuccinamic+acid
Artikel-Nr:
(BOSSBS-2072R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2072R-FITC
Lokale Artikelnummer::
BOSSBS-2072R-FITC
Beschreibung:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0156R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0156R-CY5.5
Lokale Artikelnummer::
BOSSBS-0156R-CY5.5
Beschreibung:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8339R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8339R-A750
Lokale Artikelnummer::
BOSSBS-8339R-A750
Beschreibung:
The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA) biosynthesis. Coenzyme A is an important coenzyme involved in the synthesis and oxidation of fatty acids, as well as the oxidation of pyruvate in the citric acid (Krebs) cycle. Pantothenate kinase 3 (PANK3) is a 370 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localised to the cytoplasm, PANK3 is regulated by feedback inhibition by CoA and its thioesters. PANK3 transfers a phosphate from ATP to pantothenate (Vitamin B5), resulting in formation of 4?-phosphopantothenate. Closely related to its family members, PANK1, PANK2 and PANK4, PANK3 is highly expressed in liver. Pantothenate kinase associated neurodegeneration (PKAN) results from mutations in the gene encoding PANK2, the only mitochondria targeted human PANK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12448R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12448R-A750
Lokale Artikelnummer::
BOSSBS-12448R-A750
Beschreibung:
The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. ADH5 (alcohol dehydrogenase 5 (class III)), also known as FDH (formaldehyde dehydrogenase), ADHX, ADH-3 or GSNOR, is a 374 amino acid cytoplasmic protein that belongs to the class III subfamily of alcohol dehydrogenases. Expressed ubiquitously, ADH5 uses iron as a cofactor to catalytically oxidize both long-chain primary alcohols and S-hydroxymethyl-glutathione, a product formed spontaneously between formaldehyde and glutathione. ADH5 exists as a homodimer and, via its ability to oxidize S-hydroxymethyl-glutathione and, thus, eliminate formaldehyde, functions as an important component of cellular metabolism. Genetic variations in the gene encoding ADH5 may affect drug and alcohol dependence in humans.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11288R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11288R-A680
Lokale Artikelnummer::
BOSSBS-11288R-A680
Beschreibung:
hydrolyses GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11289R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11289R-A350
Lokale Artikelnummer::
BOSSBS-11289R-A350
Beschreibung:
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11288R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11288R-A350
Lokale Artikelnummer::
BOSSBS-11288R-A350
Beschreibung:
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2537R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2537R-A350
Lokale Artikelnummer::
BOSSBS-2537R-A350
Beschreibung:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2537R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2537R-FITC
Lokale Artikelnummer::
BOSSBS-2537R-FITC
Beschreibung:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
VE:
1 * 100 µl
Artikel-Nr:
(USBI133979)
Lieferant:
US Biological
Hersteller-Artikelnummer::
133979
Lokale Artikelnummer::
USBI133979
Beschreibung:
Anti-STK25 Mouse Monoclonal Antibody [clone: 1G6]
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-2352R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2352R-CY7
Lokale Artikelnummer::
BOSSBS-2352R-CY7
Beschreibung:
Cytochromes P45 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2352R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2352R-CY3
Lokale Artikelnummer::
BOSSBS-2352R-CY3
Beschreibung:
Cytochromes P45 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
VE:
1 * 100 µl
Artikel-Nr:
(1224970.)
Lieferant:
USP
Hersteller-Artikelnummer::
1224970
Lokale Artikelnummer::
USPH1224970
Beschreibung:
USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.
VE:
1 * 20 mg
Artikel-Nr:
(BOSSBS-8339R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8339R-A488
Lokale Artikelnummer::
BOSSBS-8339R-A488
Beschreibung:
The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA) biosynthesis. Coenzyme A is an important coenzyme involved in the synthesis and oxidation of fatty acids, as well as the oxidation of pyruvate in the citric acid (Krebs) cycle. Pantothenate kinase 3 (PANK3) is a 370 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK3 is regulated by feedback inhibition by CoA and its thioesters. PANK3 transfers a phosphate from ATP to pantothenate (Vitamin B5), resulting in formation of 4’-phosphopantothenate. Closely related to its family members, PANK1, PANK2 and PANK4, PANK3 is highly expressed in liver. Pantothenate kinase associated neurodegeneration (PKAN) results from mutations in the gene encoding PANK2, the only mitochondria targeted human PANK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11277R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11277R-A350
Lokale Artikelnummer::
BOSSBS-11277R-A350
Beschreibung:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9634R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9634R-FITC
Lokale Artikelnummer::
BOSSBS-9634R-FITC
Beschreibung:
The Isocitrate dehydrogenase cytoplasmic enzyme is a homodimer of 416 residues that belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ?ketoglutarate and CO2 in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ?ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Ca2+ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg2+. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDHC is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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