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Ethyl-2-ethoxybenzoate
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Ethyl-2-ethoxybenzoate
Artikel-Nr:
(BOSSBS-1160R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1160R-A488
Lokale Artikelnummer::
BOSSBS-1160R-A488
Beschreibung:
Gelsolin is a calcium dependent actin binding protein. It is a potent modulator of actin filament length and gelation. Gelsolin has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called actin depolymerizing factor (ADF) or brevin. Human plasma and rabbit macrophage gelsolins differ by the presence of a 25 amino acid residue extension at the NH2 terminus in the human plasma gelsolin, which appears to account for the difference in relative molecular weights.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3539R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3539R-A647
Lokale Artikelnummer::
BOSSBS-3539R-A647
Beschreibung:
Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3437R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3437R-A350
Lokale Artikelnummer::
BOSSBS-3437R-A350
Beschreibung:
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6107R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6107R-A647
Lokale Artikelnummer::
BOSSBS-6107R-A647
Beschreibung:
Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6299R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6299R-A488
Lokale Artikelnummer::
BOSSBS-6299R-A488
Beschreibung:
PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6694R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6694R-A350
Lokale Artikelnummer::
BOSSBS-6694R-A350
Beschreibung:
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2621R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2621R-A647
Lokale Artikelnummer::
BOSSBS-2621R-A647
Beschreibung:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5669R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5669R-A555
Lokale Artikelnummer::
BOSSBS-5669R-A555
Beschreibung:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11424R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11424R-A680
Lokale Artikelnummer::
BOSSBS-11424R-A680
Beschreibung:
Sauvagine is a 40-residue peptide isolated and characterised from frog skin. It shares significant structural homology with and elicits similar biological responses as corticotropin-releasing factor (CRF). It has high affinity for both the CRF1 and CRF2 receptors (and low affinity for the CRF binding protein), suggesting its potential as a pharmacological tool for the study of these receptor sub-types. Due to the binding to CRF2 receptors and their role in the release of ACTH and beta-endorphin during stress, possible areas of research with this ligand include anxiety, depression and obesity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12036R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12036R-A488
Lokale Artikelnummer::
BOSSBS-12036R-A488
Beschreibung:
With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12036R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12036R-A680
Lokale Artikelnummer::
BOSSBS-12036R-A680
Beschreibung:
With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumour suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukaemias and myelodysplastic syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0224R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0224R-A647
Lokale Artikelnummer::
BOSSBS-0224R-A647
Beschreibung:
Nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Tissue specificity: Ubiquitous. It is belongs to the N-CoR nuclear receptor corepressors family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10239R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10239R-A488
Lokale Artikelnummer::
BOSSBS-10239R-A488
Beschreibung:
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-20152R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-20152R-A750
Lokale Artikelnummer::
BOSSBS-20152R-A750
Beschreibung:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5810R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5810R-A647
Lokale Artikelnummer::
BOSSBS-5810R-A647
Beschreibung:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0822R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0822R-A750
Lokale Artikelnummer::
BOSSBS-0822R-A750
Beschreibung:
DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. stabilises the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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