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(R)-(+)-2-Pyrrolidinon-5-carbons\\\\u00E4ure
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(R)-(+)-2-Pyrrolidinon-5-carbons\\\\u00E4ure
Artikel-Nr:
(BOSSBS-9133R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9133R-A750
Lokale Artikelnummer::
BOSSBS-9133R-A750
Beschreibung:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4510R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4510R-HRP
Lokale Artikelnummer::
BOSSBS-4510R-HRP
Beschreibung:
The pleiotropic IL3 (Interleukin 3) is a 15kDa cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL3 acts in hematopoiesis by controlling the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and the monocytes/macrophages. It induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes and is expressed by activated T cells, mast cells, and natural killer cells. IL3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL3 has also been shown to protect mast cells from undergoing apoptosis.
VE:
1 * 100 µl
Lieferant:
ELTEN
Beschreibung:
ESD-Sicherheitsschuh mit Obermaterial aus Rindsleder und Sohle aus Gummi-/PU (Wellmaxx Grip).
Artikel-Nr:
(BOSSBS-4216R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4216R-CY7
Lokale Artikelnummer::
BOSSBS-4216R-CY7
Beschreibung:
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4216R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4216R-CY5
Lokale Artikelnummer::
BOSSBS-4216R-CY5
Beschreibung:
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
VE:
1 * 100 µl
Lieferant:
VWR Collection
Beschreibung:
Diese Einweg-Besucherkittel, mit Kragen, werden aus ungewebtem SPP-Vlies hergestellt.
Lieferant:
UVEX
Beschreibung:
Modern, metal-free, ultra-lightweight and flexible S3 safety lace-up shoe.
Lieferant:
Sigma-Aldrich
Beschreibung:
Leupeptin hydrochloride
Lieferant:
Alfa Aesar
Beschreibung:
Inhibits bacterial mucopeptide synthesis.
Lieferant:
ELTEN
Beschreibung:
ESD work shoe made from hydrophobized nubuck leather and a PU/PU sole (Wellmaxx Flex).
Lieferant:
ABEBA
Beschreibung:
Antistatische Schuhe aus Glattleder mit atmungsaktiven Air-Mesh Textileinsätzen und leichter, kraftstoffbeständiger PU-Laufsohle.
Lieferant:
ABEBA
Beschreibung:
Antistatischer Schuh aus genarbtem Leder und mit PU-Sohle (beständig gegen tierische Fette, Öl und Kraftstoff).
Artikel-Nr:
(BOSSBS-5918R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5918R-FITC
Lokale Artikelnummer::
BOSSBS-5918R-FITC
Beschreibung:
Angiopoietin-like protein 3 (Angptl3) functions as a potent lipoprotein lipase inhibitor and is an important component of plasma triglyceride homeostasis. Angptl3 also plays a role in adipose formation and angiogenesis through its interaction with integrin ?v)beta(3). It is secreted by the liver and is functionally defined by the C-terminal fibrinogen (FBN)-like domain and an N-terminal coiled-coil domain. Angptl3 regulates circulating triglyceride levels during different nutritional states thereby mediating the feeding/fasting cycle. A deficiency of Angptl3 results in abnormally low lipid levels, and a repression of the protein may be protective against atherosclerosis. Angptl3 may also play an important role in hyperlipidemia in diabetes.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
In Western blotting, this antibody recognizes proteins in MW range of 265-400 kDa, identified as different glycoforms of EMA. The α subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The β subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Artikel-Nr:
(BOSSBS-9121R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9121R-A750
Lokale Artikelnummer::
BOSSBS-9121R-A750
Beschreibung:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
In Western blotting, this antibody recognizes proteins in MW range of 265-400 kDa, identified as different glycoforms of EMA. The α subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The β subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
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