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Aluminiumoxid,+\u03B3-Phase
Artikel-Nr:
(BOSSBS-5981R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5981R-CY5
Lokale Artikelnummer::
BOSSBS-5981R-CY5
Beschreibung:
p107 is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Lieferant:
Biotium
Beschreibung:
Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested.
Artikel-Nr:
(BOSSBS-7781R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7781R-FITC
Lokale Artikelnummer::
BOSSBS-7781R-FITC
Beschreibung:
Required for S phase entry of the cell cycle.The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested.
Lieferant:
Biotium
Beschreibung:
Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested.
Lieferant:
Hichrom Limited
Beschreibung:
Vydac MS-Säulen sind eine spätere Entwicklung von Grace für die Umkehrphasen-HPLC-Trennung von Biomolekülen.
Artikel-Nr:
(535-0279)
Lieferant:
LABCONCO
Hersteller-Artikelnummer::
7926908
Lokale Artikelnummer::
LBCP7926908
Beschreibung:
Festphasen-Röhrchen mit 1,5-ml-Stiel, 170 ml Inhalt, Für: RapidVap® N‚‚
VE:
1 * 8 ST
Lieferant:
Advanced Chromatography Technologies
Beschreibung:
Die Avantor® ACE® Excel® C18-AR-Phase nutzt einen speziell entwickelten Liganden, der eine C18-Kette mit integraler Phenylfunktionalität kombiniert und so die Vorteile von C18- und Phenyleigenschaften in einer einzigen Phase vereint. Dies kann für „standardmäßige“ C18-Säulentrennungen verwendet werden, wird aber zusätzlich für Trennungen empfohlen, bei denen Verbindungen mit aromatischer Funktionalität beteiligt sind.
Lieferant:
Advanced Chromatography Technologies
Beschreibung:
Die Avantor® ACE® Excel® C18-AR-Phase nutzt einen speziell entwickelten Liganden, der eine C18-Kette mit integraler Phenylfunktionalität kombiniert und so die Vorteile von C18- und Phenyleigenschaften in einer einzigen Phase vereint. Dies kann für „standardmäßige“ C18-Säulentrennungen verwendet werden, wird aber zusätzlich für Trennungen empfohlen, bei denen Verbindungen mit aromatischer Funktionalität beteiligt sind.
Lieferant:
TECAN TRADING
Beschreibung:
A hydrophilic/Lipophilic balanced chemistry offering selectivity to a wide range of analytes. It provides enhanced selectivity for polar species along with a unique NBE column platform. A direct alternative to Waters Oasis® HLB µElution.
Artikel-Nr:
(BOSSBS-0660R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0660R-FITC
Lokale Artikelnummer::
BOSSBS-0660R-FITC
Beschreibung:
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1148R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1148R-CY5.5
Lokale Artikelnummer::
BOSSBS-1148R-CY5.5
Beschreibung:
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1148R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1148R-CY3
Lokale Artikelnummer::
BOSSBS-1148R-CY3
Beschreibung:
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0633R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0633R-A555
Lokale Artikelnummer::
BOSSBS-0633R-A555
Beschreibung:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0633R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0633R-A350
Lokale Artikelnummer::
BOSSBS-0633R-A350
Beschreibung:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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