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Aluminum+oxide-Silicon+oxide
Artikel-Nr:
(BOSSBS-1603R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1603R-A647
Lokale Artikelnummer::
BOSSBS-1603R-A647
Beschreibung:
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1603R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1603R-A350
Lokale Artikelnummer::
BOSSBS-1603R-A350
Beschreibung:
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1446R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1446R-A750
Lokale Artikelnummer::
BOSSBS-1446R-A750
Beschreibung:
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilisation of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3996R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3996R-CY3
Lokale Artikelnummer::
BOSSBS-3996R-CY3
Beschreibung:
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. Malate dehydrogenase 1 (MDH1) is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13376R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13376R
Lokale Artikelnummer::
BOSSBS-13376R
Beschreibung:
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1874R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1874R-CY5.5
Lokale Artikelnummer::
BOSSBS-1874R-CY5.5
Beschreibung:
Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4047R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4047R-A750
Lokale Artikelnummer::
BOSSBS-4047R-A750
Beschreibung:
ACADM protein is a medium chain specific (C4 to C12 straight chain) acyl Coenzyme A dehydrogenase. The enzyme catalyses the initial step of the mitochondrial fatty acid beta oxidation pathway. ACADM expression is induced during periods of fasting, when reliance on fatty acids for energy is increased. Clinical phenotypes are associated with ACADM hereditary deficiency.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5056R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5056R-A555
Lokale Artikelnummer::
BOSSBS-5056R-A555
Beschreibung:
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11987R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11987R-FITC
Lokale Artikelnummer::
BOSSBS-11987R-FITC
Beschreibung:
CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11987R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11987R-A555
Lokale Artikelnummer::
BOSSBS-11987R-A555
Beschreibung:
CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.
VE:
1 * 100 µl
Artikel-Nr:
(ROCKBCBT-100)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
BCBT-100
Lokale Artikelnummer::
ROCKBCBT-100
Beschreibung:
BCIP/TNBT Membrane Alkaline Phosphatase Substrate is an artificially manufactured chromogenic substrate for use in sensitive colorimetric assays. BCIP/TNBT can be utilized in ELISA, in situ hybridization, and IHC. Alkaline phosphatase hydrolyzes the BCIP to 5-bromo-4-chloro-3-indole, which is oxidized by oxygen in the atmosphere, yielding a blue dye. In the presence of TNBT, an insoluble dark blue precipitate is formed after a reduction reaction instead.
VE:
1 * 100 mL
Artikel-Nr:
(BOSSBS-6989R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6989R
Lokale Artikelnummer::
BOSSBS-6989R
Beschreibung:
H6PD (hexose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein) is a 789 amino acid protein encoded by the human gene H6PD. The N-terminal section of H6PD belongs to the glucose-6-phosphate dehydrogenase family, while the C-terminal section belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily. H6PD is responsible primarily for the oxidation of glucose-6-phosphate and glucose. It also oxidizes other hexose-6-phosphates. H6PD catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor for the reductase activity of 11∫-hydroxysteroid dehydrogenase type 1, which converts hormonally inactive cortisone to active cortisol (in rodents, 11-dehydrocorticosterone to corticosterone).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11734R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11734R
Lokale Artikelnummer::
BOSSBS-11734R
Beschreibung:
Located in the mitochondrial inner membrane, mitochondrial complex I is the first and largest enzyme in the electron transport chain of oxidative phosphorylation. By oxidizing NADH that is produced in the Krebs cycle, this complex utilizes the two electrons to reduce ubiquinone to ubiquinol, thereby initiating the passage of electrons to successive complexes and ultimately leading to the reduction of oxygen to water. Mitochondrial complex I consists of over 40 subunits and is of considerable clinical interest since defects in any of the subunits can lead to various myopathies and neuropathies. As a subunit of mitochondrial complex I, NDUFS7 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 7), also designated NADH-ubiquinone oxidoreductase 20 kDa subunit, is a 213 amino acid protein that is suggested to be required for catalytic activity. Defects in the gene encoding NDUFS7 are the cause of Leigh syndrome, a severe neurological disorder that is characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7533R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7533R-CY7
Lokale Artikelnummer::
BOSSBS-7533R-CY7
Beschreibung:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7533R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7533R-A350
Lokale Artikelnummer::
BOSSBS-7533R-A350
Beschreibung:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9634R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9634R-CY5
Lokale Artikelnummer::
BOSSBS-9634R-CY5
Beschreibung:
The Isocitrate dehydrogenase cytoplasmic enzyme is a homodimer of 416 residues that belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ?ketoglutarate and CO2 in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ?ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Ca2+ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg2+. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDHC is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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