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Aluminum+oxide-Silicon+oxide
Artikel-Nr:
(BOSSBS-8339R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8339R-A680
Lokale Artikelnummer::
BOSSBS-8339R-A680
Beschreibung:
The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA) biosynthesis. Coenzyme A is an important coenzyme involved in the synthesis and oxidation of fatty acids, as well as the oxidation of pyruvate in the citric acid (Krebs) cycle. Pantothenate kinase 3 (PANK3) is a 370 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localised to the cytoplasm, PANK3 is regulated by feedback inhibition by CoA and its thioesters. PANK3 transfers a phosphate from ATP to pantothenate (Vitamin B5), resulting in formation of 4?-phosphopantothenate. Closely related to its family members, PANK1, PANK2 and PANK4, PANK3 is highly expressed in liver. Pantothenate kinase associated neurodegeneration (PKAN) results from mutations in the gene encoding PANK2, the only mitochondria targeted human PANK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4047R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4047R-HRP
Lokale Artikelnummer::
BOSSBS-4047R-HRP
Beschreibung:
ACADM protein is a medium chain specific (C4 to C12 straight chain) acyl Coenzyme A dehydrogenase. The enzyme catalyzes the initial step of the mitochondrial fatty acid beta oxidation pathway. ACADM expression is induced during periods of fasting, when reliance on fatty acids for energy is increased. Clinical phenotypes are associated with ACADM hereditary deficiency.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1874R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1874R-A555
Lokale Artikelnummer::
BOSSBS-1874R-A555
Beschreibung:
Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1874R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1874R-A647
Lokale Artikelnummer::
BOSSBS-1874R-A647
Beschreibung:
Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2072R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2072R-CY7
Lokale Artikelnummer::
BOSSBS-2072R-CY7
Beschreibung:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13339R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13339R
Lokale Artikelnummer::
BOSSBS-13339R
Beschreibung:
GFM2 is a mitochondrial translation elongation factor. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5049R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5049R-CY5
Lokale Artikelnummer::
BOSSBS-5049R-CY5
Beschreibung:
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1926R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1926R-CY3
Lokale Artikelnummer::
BOSSBS-1926R-CY3
Beschreibung:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3501R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3501R-CY5.5
Lokale Artikelnummer::
BOSSBS-3501R-CY5.5
Beschreibung:
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11734R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11734R-A647
Lokale Artikelnummer::
BOSSBS-11734R-A647
Beschreibung:
Located in the mitochondrial inner membrane, mitochondrial complex I is the first and largest enzyme in the electron transport chain of oxidative phosphorylation. By oxidizing NADH that is produced in the Krebs cycle, this complex utilizes the two electrons to reduce ubiquinone to ubiquinol, thereby initiating the passage of electrons to successive complexes and ultimately leading to the reduction of oxygen to water. Mitochondrial complex I consists of over 40 subunits and is of considerable clinical interest since defects in any of the subunits can lead to various myopathies and neuropathies. As a subunit of mitochondrial complex I, NDUFS7 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 7), also designated NADH-ubiquinone oxidoreductase 20 kDa subunit, is a 213 amino acid protein that is suggested to be required for catalytic activity. Defects in the gene encoding NDUFS7 are the cause of Leigh syndrome, a severe neurological disorder that is characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8259R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8259R-CY7
Lokale Artikelnummer::
BOSSBS-8259R-CY7
Beschreibung:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8259R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8259R-CY3
Lokale Artikelnummer::
BOSSBS-8259R-CY3
Beschreibung:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11277R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11277R
Lokale Artikelnummer::
BOSSBS-11277R
Beschreibung:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8339R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8339R-A647
Lokale Artikelnummer::
BOSSBS-8339R-A647
Beschreibung:
The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA) biosynthesis. Coenzyme A is an important coenzyme involved in the synthesis and oxidation of fatty acids, as well as the oxidation of pyruvate in the citric acid (Krebs) cycle. Pantothenate kinase 3 (PANK3) is a 370 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK3 is regulated by feedback inhibition by CoA and its thioesters. PANK3 transfers a phosphate from ATP to pantothenate (Vitamin B5), resulting in formation of 4’-phosphopantothenate. Closely related to its family members, PANK1, PANK2 and PANK4, PANK3 is highly expressed in liver. Pantothenate kinase associated neurodegeneration (PKAN) results from mutations in the gene encoding PANK2, the only mitochondria targeted human PANK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11277R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11277R-A680
Lokale Artikelnummer::
BOSSBS-11277R-A680
Beschreibung:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen Signalling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9634R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9634R-A555
Lokale Artikelnummer::
BOSSBS-9634R-A555
Beschreibung:
The Isocitrate dehydrogenase cytoplasmic enzyme is a homodimer of 416 residues that belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ?ketoglutarate and CO2 in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ?ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Ca2+ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg2+. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDHC is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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