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N1-Methylbenzene-1,2-diamine+dihydrochloride
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N1-Methylbenzene-1,2-diamine+dihydrochloride
Artikel-Nr:
(BOSSBS-8551R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8551R-A750
Lokale Artikelnummer::
BOSSBS-8551R-A750
Beschreibung:
Nitrotyrosine is a marker for inflammation and nitric oxide (NO) production and is formed in the presence of the active metabolite NO. Because nitrotyrosine is a stable product of multiple pathways, such as the formation of peroxynitrite, its plasma concentration may be a useful determinant of NO-dependent damage in vivo. Nitrotyrosine has been detected in inflammatory processes such as septic shock, rheumatoid arthritis, celiac disease, atherosclerotic plaques and chronic renal failure.
VE:
1 * 100 µl
Artikel-Nr:
(CHMP003844-100)
Lieferant:
CHEMPUR
Hersteller-Artikelnummer::
003844-100
Lokale Artikelnummer::
CHMP003844-100
Beschreibung:
Germanium(IV)oxid
VE:
1 * 100 g
Artikel-Nr:
(BOSSBS-13459R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13459R-CY7
Lokale Artikelnummer::
BOSSBS-13459R-CY7
Beschreibung:
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13339R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13339R-A680
Lokale Artikelnummer::
BOSSBS-13339R-A680
Beschreibung:
GFM2 is a mitochondrial translation elongation factor. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0163R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0163R-A488
Lokale Artikelnummer::
BOSSBS-0163R-A488
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0163R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0163R-FITC
Lokale Artikelnummer::
BOSSBS-0163R-FITC
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3447R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3447R-HRP
Lokale Artikelnummer::
BOSSBS-3447R-HRP
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3447R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3447R-A647
Lokale Artikelnummer::
BOSSBS-3447R-A647
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5015R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5015R-CY5
Lokale Artikelnummer::
BOSSBS-5015R-CY5
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3140R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3140R-CY3
Lokale Artikelnummer::
BOSSBS-3140R-CY3
Beschreibung:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10150R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10150R-A680
Lokale Artikelnummer::
BOSSBS-10150R-A680
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyse the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13339R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13339R-CY3
Lokale Artikelnummer::
BOSSBS-13339R-CY3
Beschreibung:
GFM2 is a mitochondrial translation elongation factor. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA.
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
Indium(III)oxid, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-3140R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3140R-CY7
Lokale Artikelnummer::
BOSSBS-3140R-CY7
Beschreibung:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0267R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0267R-CY7
Lokale Artikelnummer::
BOSSBS-0267R-CY7
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5566R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5566R-CY3
Lokale Artikelnummer::
BOSSBS-5566R-CY3
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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