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Aluminum+oxide-Silicon+oxide
Artikel-Nr:
(BOSSBS-3614R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3614R-CY7
Lokale Artikelnummer::
BOSSBS-3614R-CY7
Beschreibung:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5566R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5566R-A680
Lokale Artikelnummer::
BOSSBS-5566R-A680
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5015R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5015R-CY5.5
Lokale Artikelnummer::
BOSSBS-5015R-CY5.5
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6365R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6365R
Lokale Artikelnummer::
BOSSBS-6365R
Beschreibung:
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10150R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10150R-CY7
Lokale Artikelnummer::
BOSSBS-10150R-CY7
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10150R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10150R-CY5
Lokale Artikelnummer::
BOSSBS-10150R-CY5
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(SIAL678945-25ML)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
678945-25ML
Lokale Artikelnummer::
SIAL678945-25ML
Beschreibung:
Kupfer(I)oxid, Sigma-Aldrich®
VE:
1 * 25 mL
Artikel-Nr:
(SIAL697222-25G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
697222-25G
Lokale Artikelnummer::
SIAL697222-25G
Beschreibung:
Tantal(V)oxid, Sigma-Aldrich®
VE:
1 * 25 g
Artikel-Nr:
(BOSSBS-3278R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3278R-CY5.5
Lokale Artikelnummer::
BOSSBS-3278R-CY5.5
Beschreibung:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.
VE:
1 * 100 µl
Artikel-Nr:
(SIAL377201-500G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
377201-500G
Lokale Artikelnummer::
SIAL377201-500G
Beschreibung:
Mangan(II)oxid, Sigma-Aldrich®
VE:
1 * 500 g
Artikel-Nr:
(BOSSBS-13339R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13339R-A555
Lokale Artikelnummer::
BOSSBS-13339R-A555
Beschreibung:
GFM2 is a mitochondrial translation elongation factor. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA.
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
Niob(V)oxid, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-11397R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11397R
Lokale Artikelnummer::
BOSSBS-11397R
Beschreibung:
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
VE:
1 * 100 µl
Artikel-Nr:
(ABCRAB122123.0025)
Lieferant:
ABCR
Hersteller-Artikelnummer::
AB122123.0025
Lokale Artikelnummer::
ABCRAB122123.0025
Beschreibung:
Tantal(V)oxid ≥99,8% (99.95+%-Ta)
VE:
1 * 25 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-13545R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13545R-A350
Lokale Artikelnummer::
BOSSBS-13545R-A350
Beschreibung:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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