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Aluminum+oxide-Silicon+oxide
Artikel-Nr:
(BOSSBS-3821R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3821R
Lokale Artikelnummer::
BOSSBS-3821R
Beschreibung:
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11693R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11693R
Lokale Artikelnummer::
BOSSBS-11693R
Beschreibung:
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).
VE:
1 * 100 µl
Lieferant:
DELTALAB
Beschreibung:
PP-Spatel mit abgerundeten Kanten. Steriles Modell ist mittels Ethylenoxid sterilisiert. Packung enthält Anweisungen zur Verwendung.
Artikel-Nr:
(PIER34002)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
34002
Lokale Artikelnummer::
PIER34002
Beschreibung:
DAB (3,3'-diaminodbenzidine) is a sensitive colorimetric substrate used with horseradish peroxidase (HRP) in immunohistochemistry and immunoblotting applications. HRP catalyses hydrogen peroxide oxidation of substrates such as DAB. Electrons are transferred by HRP from the DAB to the peroxide to yield an insoluble brown product.
VE:
1 * 1 KIT
Artikel-Nr:
(412-2105)
Lieferant:
Retsch GmbH
Hersteller-Artikelnummer::
22.456.0004
Lokale Artikelnummer::
RETS22.456.0004
Beschreibung:
Scheibensatz, Zirkoniumoxid
VE:
1 * 1 ST
Artikel-Nr:
(BSBTA00760-1)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
A00760-1
Lokale Artikelnummer::
BSBTA00760-1
Beschreibung:
Rabbit IgG polyclonal antibody for Oxidized low-density lipoprotein receptor 1(OLR1) detection. Tested with WB in Human.
VE:
1 * 100 µG
Artikel-Nr:
(PROOMM0127.00)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
MM0127.00
Lokale Artikelnummer::
PROOMM0127.00
Beschreibung:
(±)-α-Liponsäure
VE:
1 * 500 mg
Artikel-Nr:
(MOLE67943083-5G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
67943083-5G
Lokale Artikelnummer::
MOLE67943083-5G
Beschreibung:
TATU (O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumtetrafluoroborat)
VE:
1 * 5 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PROOMM0528.09)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
MM0528.09
Lokale Artikelnummer::
PROOMM0528.09
Beschreibung:
Organic Standard, N-Phenyl-N-[cis,trans-1-oxido-1-(2-phenylethyl)piperidin-4-yl]propanamide hydrochloride
VE:
1 * 100 mg
Artikel-Nr:
(PRSI26-328)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-328
Lokale Artikelnummer::
PRSI26-328
Beschreibung:
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
VE:
1 * 50 µG
Lieferant:
Alfa Aesar
Beschreibung:
Ammoniummetavanadat ≥99,0% ACS
Artikel-Nr:
(PRSI79-487)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-487
Lokale Artikelnummer::
PRSI79-487
Beschreibung:
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
VE:
1 * 100 µG
Lieferant:
Honeywell Chemicals
Beschreibung:
Essigsäureanhydrid ≥99% (durch GC), Puriss. p.a. ACS, ISO, Reag. Ph. Eur., Fluka™
Artikel-Nr:
(SIAL241288-50G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
241288-50G
Lokale Artikelnummer::
SIAL241288-50G
Beschreibung:
Triphenylphosphat, Sigma-Aldrich®
VE:
1 * 50 g
Artikel-Nr:
(BOSSBS-4005R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4005R-HRP
Lokale Artikelnummer::
BOSSBS-4005R-HRP
Beschreibung:
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1687R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1687R-CY5
Lokale Artikelnummer::
BOSSBS-1687R-CY5
Beschreibung:
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-133 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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