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1,4-Dibromo-3,5-difluorobenzene
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1,4-Dibromo-3,5-difluorobenzene
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
AM095 free acid is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
Artikel-Nr:
(ACRO269010010)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
269010010
Lokale Artikelnummer::
ACRO269010010
Beschreibung:
CAS No.:
VE:
1 * 1 kg
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Artikel-Nr:
(BTIUBNUM0715-50)
Lieferant:
Biotium
Hersteller-Artikelnummer::
BNUM0715-50
Lokale Artikelnummer::
BTIUBNUM0715-50
Beschreibung:
This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
VE:
1 * 50 µl
Artikel-Nr:
(BOSSBS-0497R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0497R-CY5.5
Lokale Artikelnummer::
BOSSBS-0497R-CY5.5
Beschreibung:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
VE:
1 * 100 µl
Artikel-Nr:
(BTIUBNUM0714-50)
Lieferant:
Biotium
Hersteller-Artikelnummer::
BNUM0714-50
Lokale Artikelnummer::
BTIUBNUM0714-50
Beschreibung:
This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
VE:
1 * 50 µl
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Artikel-Nr:
(BOSSBS-0497R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0497R-CY5
Lokale Artikelnummer::
BOSSBS-0497R-CY5
Beschreibung:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12902R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12902R
Lokale Artikelnummer::
BOSSBS-12902R
Beschreibung:
EGF response factor 1 is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating cys-his motif. TIS11B is an mRNA binding protein and is known to interact with the 3’-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11706R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11706R
Lokale Artikelnummer::
BOSSBS-11706R
Beschreibung:
The aldo-keto reductase 7 (AKR7) family includes AKR7A2, AKR7A3 and AKR7A4 in human, AKR7A5 in mouse and AKR7A2 in rat, all of which function in the metabolism of aflatoxin B(1) and other dicarbonyl-containing compounds. More specifically, AKR7A proteins are involved in the metabolism of compounds with ketone groups on adjacent carbon atoms in a broad range of tissues, notably the liver. The human AKR7A2 gene maps to human chromosome 1p35-36, a region frequently deleted in sporadic colorectal cancer. The functional significance of this correlation lies in the constitutive expression of AKR7A2 in human liver to eliminate aflatoxin (an environmental carcinogen), thus acting as an endogenous chemo-preventative agent.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Appearance: Clear colorless to light yellow Liquid
Lieferant:
VWR Collection
Beschreibung:
Entwickelt, um mehrere Reagenzgläser, Reagenzglasgestelle, Fläschchen oder Zylinder zu halten. Die Wirbelwirkung wird erzeugt, indem die Oberseite des Gefäßes an Ort und Stelle gehalten wird, während sich die Unterseite frei in einer definierten Umlaufbahn bewegen kann. Zwei Edelstahlpfosten halten die Trägerplatte sicher an Ort und Stelle und sorgen so für leises, klapperfreies Mischen. Die Trägerplatte lässt sich leicht einstellen, indem Sie die Knöpfe lösen und die Trägerplatte nach oben und unten bewegen. Die kreisförmige Nut um die Oberseite des höheren Pfostens ermöglicht es, die Trägerplatte vom Tablett wegzuschwenken, um Proben einfach zu entnehmen. Die Saugnapffüße dämpfen die Bewegung und verhindern, dass sich die Einheit auf der Werkbank bewegt. Aus Edelstahl mit korrosionsbeständiger Farbe. Ausgestattet mit einem leistungsstarken Permanentmagnetmotor mit abgedichteten Kugellagern. Der Motor ist für Dauerbetrieb ausgelegt.
Lieferant:
VWR Chemicals
Beschreibung:
Agarose high resolution is optimised to give exceptional separation on agarose of nucleic acid fragments below 1000 base pairs, and differing by only a few base pairs. It retains the low gelling characteristics of the standard Agarose HR, and offers significantly increased gel strength at the expense of a higher melting temperature. This results in gels which are flexible and easy to handle. These properties make it the agarose of choice for analytical gel separations to check the quality and size of amplified fragments, and for use in restriction mapping involving small digestion fragments.
Lieferant:
Honeywell Chemicals
Beschreibung:
1-Nitroso-2-naphthol-3,6-disulfonsäure Dinatriumsalz für spektrophotometrische Bestimmung von Co, Fe, K, Ag, Ba, Ca, Co, Fe, Ni, Pb, Fluka™
Lieferant:
Biotium
Beschreibung:
Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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