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Bis(3-nitrophenyl)disulfid
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Bis(3-nitrophenyl)disulfid
Artikel-Nr:
(PRSI91-842)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-842
Lokale Artikelnummer::
PRSI91-842
Beschreibung:
Bactericidal permeability-increasing protein(BPI for short), is a secreted protein which belongs to the BPI/LBP/Plunc superfamily, BPI/LBP family. It exists as a monomer or a disulfide-linked homodimer. The cytotoxic action of BPI is limited to many species of Gram-negative bacteria. This specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. BPI has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, and this activity is inhibited by LPS from P.aeruginosa.
VE:
1 * 50 µG
Lieferant:
MP Biomedicals
Beschreibung:
Storage: Store at +4 °C, store under nitrogen
Glutathione is the major low molecular weight thiol compound of the living plant or animal cell. It is a tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides. The sulfhydryl (thiol) group (SH) of cysteine serves as a proton donor and is responsible for the biological activity of glutathione. Glutathione suppresses human immunodeficiency virus expression in chronically infected monocytic cells. It is a useful tripeptide involved in many aspects of metabolism, including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds. Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
Artikel-Nr:
(PRSI92-070)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-070
Lokale Artikelnummer::
PRSI92-070
Beschreibung:
B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells. CD72 is a ligand for CD5. CD72 associates with CD5, interacts with PTPN6/SHP-1 and plays a role in B-cell proliferation and differentiation. CD72 associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulation and dampens BCR signaling through interactions with the phosphatase SHP-1.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-393)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-393
Lokale Artikelnummer::
PRSI92-393
Beschreibung:
Amiloride-sensitive amine oxidase (AOC1) belongs to the copper/topaquinone oxidase family. The protein exists as homodimer by disulfide and mainly located in placenta and kidney. AOC1 catalyses the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumour formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. The activity of this protein can be inhibited by amiloride in a competitive manner. It is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.
VE:
1 * 50 µG
Lieferant:
Sigma-Aldrich
Beschreibung:
Bis(2-ethylhexyl)phthalat, Supelco®
Artikel-Nr:
(431125-20MG)
Lieferant:
SIGMA ALDRICH MICROSCOPY
Hersteller-Artikelnummer::
431125-20MG
Lokale Artikelnummer::
SIAM431125-20MG
Beschreibung:
Glutaraldehyde bis(2,4-dinitrophenylhydrazone) analytischer Standard, zur Umweltanalyse, Sigma-Aldrich®
VE:
1 * 20 mg
Artikel-Nr:
(PRSIXW-8099)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XW-8099
Lokale Artikelnummer::
PRSIXW-8099
Beschreibung:
FUNCTION: Also acts as the receptor for echovirus 7 and related viruses (echoviruses 13, 21, 29 and 33).
SUBUNIT: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). PTM: The Ser/Thr-rich domain is heavily O-glycosylated. SIMILARITY: Contains 4 Sushi (CCP/SCR) domains. SUBCELLULAR LOCATION: Attached to the membrane by a GPI-anchor (isoform 2). TISSUE SPECIFICITY: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
VE:
1 * 50 µG
Lieferant:
Sigma-Aldrich
Beschreibung:
α-Chymotrypsin is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. Molecular weight of this enzyme is found to be 25 kDa. Its pI is 8,75. It selectively hydrolyses peptide bonds on the C-terminal side of tyrosine, phenylalanine, tryptophan, and leucine. Ca²⁺ activates and stabilizes the enzyme. The enzyme is inhibited by diisopropyl fluorophosphate (DFP), phenylmethanesulfonyl fluoride (PMSF), N-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK), chymostatin, aprotinin, α1-antitrypsin, α2-macroglobulin, 10 mM Cu²⁺ and Hg²⁺.A serine protease that hydrolyzes peptide bonds with aromatic or large hydrophobic side chains (Tyr, Trp, Phe, Met, Leu) on the carboxyl end of the bond.
Artikel-Nr:
(PRSI33-997)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-997
Lokale Artikelnummer::
PRSI33-997
Beschreibung:
TFF1/Breast cancer estrogen inducible protein pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. TFF1/pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. TFF1 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-401)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-401
Lokale Artikelnummer::
PRSI33-401
Beschreibung:
Recognises an N-glycosylated glycoprotein of 120 kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3 (WS: IV & V). Its epitope localizes in the D2 extracellular domain and is resistant to neuraminidase and proteases. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signalling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This mAb inhibits primary mixed lymphocyte culture (mlC) but not secondary mlC, cytotoxicity or proliferation induced by mitogens. It blocks binding of NK1-L16 stimulated T cells to L cells expressing CD50. This mAb is excellent for staining of formalin/paraffin tissues.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI91-927)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-927
Lokale Artikelnummer::
PRSI91-927
Beschreibung:
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13R alpha1 with low affinity and triggers association of IL4R alpha, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13R alpha2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI7459)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7459
Lokale Artikelnummer::
PRSI7459
Beschreibung:
The WAP four-disulfide core domain protein 2 (WFDC2), also known as epididymal protein 4, is a member of the WFDC domain family, a family of proteins that is characterized by the presence of Whey Acidic Protein (WAP) domain, and is highly expressed in the lung and salivary gland (1,2). Members of this family include SLPI and elafin, antiproteinases involved in the innate immune system. WFDC2 has been proposed to play a critical role in tumor formation and growth in ovarian cancer cells through the regulation of growth- and apoptosis-associated genes and may thus be a potential therapeutic target for epithelial ovarian cancer.
VE:
1 * 100 µG
Artikel-Nr:
(ROCK711-105-002)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
711-105-002
Lokale Artikelnummer::
ROCK711-105-002
Beschreibung:
This product has been assayed against 1.0 µg of Rabbit IgG in a standard capture ELISA using pNPP p-nitrophenyl phosphate code # NPP-10 as a substrate for 30 minutes at room temperature.
VE:
1 * 500 µG
Artikel-Nr:
(PRSI90-469)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-469
Lokale Artikelnummer::
PRSI90-469
Beschreibung:
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-466)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-466
Lokale Artikelnummer::
PRSI90-466
Beschreibung:
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
VE:
1 * 10 µG
Artikel-Nr:
(36735-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
36735-1G
Lokale Artikelnummer::
SUPL36735-1G
Beschreibung:
Bis(2-ethylhexyl)phthalat, Supelco®
VE:
1 * 1 g
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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