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(±)11(12)-EET+methyl+ester
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(±)11(12)-EET+methyl+ester
Artikel-Nr:
(BOSSBS-12676R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12676R-CY7
Lokale Artikelnummer::
BOSSBS-12676R-CY7
Beschreibung:
Complete remission of acute promyelocytic leukemia can be achieved by treating patients with retinoic acid, and PML-RAR-a (promyelocytic leukemia-retinoic acid receptor alpha fusion protein) plays a major role in mediating retinoic acid effects in leukemia cells. The retinoic acid-induced gene, PRAM-1 (PML-RAR-a target gene encoding an adaptor molecule 1) encodes an adaptor protein which is expressed and modulated during normal human myelopoiesis. PRAM-1 expression is hindered by expression of PML-RAR-a. The 718 amino acid PRAM-1 protein contains eight N-terminal proline-rich repeats and several proline residues that are clustered as type I or type II SH3 recognition motifs. PRAM-1 demonstrates expression in hematopoietic tissues and lung.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6191R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6191R
Lokale Artikelnummer::
BOSSBS-6191R
Beschreibung:
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6980R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6980R-CY3
Lokale Artikelnummer::
BOSSBS-6980R-CY3
Beschreibung:
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates (1). Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP) (1-3). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization (4-6). Evidence suggests that AKAP 79 and AKAP 150 are both capable of anchoring PKA to postsynaptic densities (PSD), which are a network of proteins located on the internal surfaces of excitatory synapses.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3216R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3216R-CY5.5
Lokale Artikelnummer::
BOSSBS-3216R-CY5.5
Beschreibung:
HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8866R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8866R-CY5.5
Lokale Artikelnummer::
BOSSBS-8866R-CY5.5
Beschreibung:
Enzymes known as phosphatidylserine decarboxylases (PSDs) catalyze the formation of phosphatidylethanolamine from phosphatidylserine via phosphatidylserine decarboxylation. Type I PSDs contain LGST motifs and are found in bacteria and eukaryotic mitochondria, whereas type II PSDs contain GGST motifs and are found in eukaryotic endomembrane systems. PISD (phosphatidylserine decarboxylase), also known as phosphatidylserine decarboxylase proenzyme, PSDC, PSD, PSSC, DJ858B16, dJ858B16.2 or DKFZp566G2246, is a 408 amino acid a type I phosphatidylserine decarboxylase that localizes to the inner mitochondrial membrane. PISD contains a conserved LGST motif which is cleaved to produce two isoforms known as PISD α and PISD β. PISD is capable of forming a heterodimer and is highly expressed in liver and testis. The gene encoding PISD maps to human chromosome 22q12.2.
VE:
1 * 100 µl
Artikel-Nr:
(31277-100G)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
31277-100G
Lokale Artikelnummer::
HONC31277-100G
Beschreibung:
Cobalt(II)chlorid Hexahydrat 98-102%, Puriss. p.a. ACS, Reag. Ph. Eur., Fluka™
VE:
1 * 100 g
Lieferant:
Biotium
Beschreibung:
This MAb reacts with the HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Artikel-Nr:
(HONE01258.9050)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
01258.9050
Lokale Artikelnummer::
HONE01258.9050
Beschreibung:
Nickel(II)fluorid Tetrahydrat
VE:
1 * 50 kg
Lieferant:
Spectrum Chemical
Beschreibung:
Manganese Chloride, Tetrahydrate, USP is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN) to maintain Manganese serum levels. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Lieferant:
ABCR
Beschreibung:
[1,1'-Bis(diphenylphosphino)ferrocen]palladium(II)chlorid-Dichlormethan-Komplex
Lieferant:
MP Biomedicals
Beschreibung:
Cobalt chloride is utilized in commercial applications such as electroplating, catalyst preparation, painting on glass and porcelain, and in the manufacture of vitamin B12.
Artikel-Nr:
(BOSSBS-8242R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8242R-A350
Lokale Artikelnummer::
BOSSBS-8242R-A350
Beschreibung:
CTDSPL2 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2), also known as HSPC058 or HSPC129, is a 466 amino acid protein that contains one FCP1 homology domain and belongs to the CTDSPL2 family. Existing as two alternatively spliced isoforms, CTDSPL2 is thought to function as a phosphatase and is encoded by a gene that maps to human chromosome 15q15.3. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and comprises about 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8242R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8242R-FITC
Lokale Artikelnummer::
BOSSBS-8242R-FITC
Beschreibung:
CTDSPL2 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2), also known as HSPC058 or HSPC129, is a 466 amino acid protein that contains one FCP1 homology domain and belongs to the CTDSPL2 family. Existing as two alternatively spliced isoforms, CTDSPL2 is thought to function as a phosphatase and is encoded by a gene that maps to human chromosome 15q15.3. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and comprises about 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
VE:
1 * 100 µl
Lieferant:
Honeywell Chemicals
Beschreibung:
Eisen(II)sulfat Heptahydrat 99,5-104,5% (durch Manganometrie), Puriss., erfüllt analytische Spezifikationen von BP, Ph. Eur., USP, FCC, Fluka™
Artikel-Nr:
(COBBST-8328-5G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
ST-8328-5G
Lokale Artikelnummer::
COBBST-8328-5G
Beschreibung:
[1,1'-Bis(diphenylphosphino)ferrocen]palladium(II)chlorid-Dichlormethan-Komplex
VE:
1 * 5 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-3073R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3073R-A680
Lokale Artikelnummer::
BOSSBS-3073R-A680
Beschreibung:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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