Copper(II)+gluconate
Artikel-Nr:
(BOSSBS-7896R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7896R-FITC
Lokale Artikelnummer::
BOSSBS-7896R-FITC
Beschreibung:
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6947R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6947R-A680
Lokale Artikelnummer::
BOSSBS-6947R-A680
Beschreibung:
KRT82 is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerises with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6947R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6947R-A350
Lokale Artikelnummer::
BOSSBS-6947R-A350
Beschreibung:
KRT82 is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0268R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0268R-A555
Lokale Artikelnummer::
BOSSBS-0268R-A555
Beschreibung:
Neurobeachin binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. It may anchor the kinase to cytoskeletal and/or organelle-associated proteins. Neurobeachin, is also a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site for the type II regulatory subunit of protein kinase A. Neurobeachin is peripherally associated with pleomorphic tubulovesicular endomembranes near the trans sides of Golgi stacks and throughout the cell body and cell processes. It is also found in a subpopulation of synapses, where it is concentrated at the postsynaptic plasma membrane.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0268R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0268R-A350
Lokale Artikelnummer::
BOSSBS-0268R-A350
Beschreibung:
Neurobeachin binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. It may anchor the kinase to cytoskeletal and/or organelle-associated proteins. Neurobeachin, is also a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site for the type II regulatory subunit of protein kinase A. Neurobeachin is peripherally associated with pleomorphic tubulovesicular endomembranes near the trans sides of Golgi stacks and throughout the cell body and cell processes. It is also found in a subpopulation of synapses, where it is concentrated at the postsynaptic plasma membrane.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0268R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0268R
Lokale Artikelnummer::
BOSSBS-0268R
Beschreibung:
Neurobeachin binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. It may anchor the kinase to cytoskeletal and/or organelle-associated proteins. Neurobeachin, is also a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site for the type II regulatory subunit of protein kinase A. Neurobeachin is peripherally associated with pleomorphic tubulovesicular endomembranes near the trans sides of Golgi stacks and throughout the cell body and cell processes. It is also found in a subpopulation of synapses, where it is concentrated at the postsynaptic plasma membrane.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4237R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4237R-A350
Lokale Artikelnummer::
BOSSBS-4237R-A350
Beschreibung:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4237R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4237R-A488
Lokale Artikelnummer::
BOSSBS-4237R-A488
Beschreibung:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4237R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4237R-A555
Lokale Artikelnummer::
BOSSBS-4237R-A555
Beschreibung:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0644R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0644R-CY5
Lokale Artikelnummer::
BOSSBS-0644R-CY5
Beschreibung:
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Zinkchlorid 99.99% (bezogen auf die Metalle der seltenen Erden), reinst
Artikel-Nr:
(BOSSBS-3743R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3743R
Lokale Artikelnummer::
BOSSBS-3743R
Beschreibung:
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12920R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12920R
Lokale Artikelnummer::
BOSSBS-12920R
Beschreibung:
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1913R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1913R-FITC
Lokale Artikelnummer::
BOSSBS-1913R-FITC
Beschreibung:
Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3. MMP8 is heavily glycosylated, and the zymogen has a mass of 85 Kd. The zymogen is quickly activated to the 64 Kd form, and this breaks down to a cascade of active forms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7734R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7734R-HRP
Lokale Artikelnummer::
BOSSBS-7734R-HRP
Beschreibung:
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4. hCAP-D3 is a regulatory non-SMC subunit of the condensin II complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3873R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3873R-A488
Lokale Artikelnummer::
BOSSBS-3873R-A488
Beschreibung:
ATG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
VE:
1 * 100 µl
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