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DIAGNOSTIC+SYSTEMS+DIASYS
Artikel-Nr:
(BOSSBS-11963R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11963R-A750
Lokale Artikelnummer::
BOSSBS-11963R-A750
Beschreibung:
There are three SorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, SorCS1, SorCS2 and SorCS3 genes are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS2 (sortilin-related VPS10 domain containing receptor 2) is a 1150 amino acid single-pass type I membrane protein that is highly expressed in brain and kidney. Containing six BNR repeats and a single PKD domain, SorCS2 is encoded by a gene that maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13087R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13087R-HRP
Lokale Artikelnummer::
BOSSBS-13087R-HRP
Beschreibung:
The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11963R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11963R-HRP
Lokale Artikelnummer::
BOSSBS-11963R-HRP
Beschreibung:
There are three SorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, SorCS1, SorCS2 and SorCS3 genes are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS2 (sortilin-related VPS10 domain containing receptor 2) is a 1,150 amino acid single-pass type I membrane protein that is highly expressed in brain and kidney. Containing six BNR repeats and a single PKD domain, SorCS2 is encoded by a gene that maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
VE:
1 * 100 µl
Lieferant:
Spectrum Chemical
Beschreibung:
Tergitol™ 15-S-9, Surfactant is a non-ionic secondary alcohol ethoxylate surfactant and is an excellent emulsifier and detergent, enhances paint thickener efficiency and aids in rinse-ability of solvent-based systems. This product is suggested for use in cleaners, prewash spotters and paints and coatings.
Artikel-Nr:
(BOSSBS-1459R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1459R-CY7
Lokale Artikelnummer::
BOSSBS-1459R-CY7
Beschreibung:
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3654R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3654R-A750
Lokale Artikelnummer::
BOSSBS-3654R-A750
Beschreibung:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1459R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1459R-CY5.5
Lokale Artikelnummer::
BOSSBS-1459R-CY5.5
Beschreibung:
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8411R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8411R
Lokale Artikelnummer::
BOSSBS-8411R
Beschreibung:
Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins that may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. GAPR-1 (Golgi-associated plant pathogenesis-related protein 1), also known as GLIPR2, is a 154 amino acid lipid anchor protein belonging to the CRISP family. GAPR-1 also shares similarity with the pathogenesis-related protein (PR) superfamily, and may play an important role in the immune system. Existing as a homodimer, GAPR-1 is highly expressed in lung and peripheral leukocytes with minor expression in liver and kidney. Containing a conserved sperm-coating protein (SCP) domain, GAPR-1 binds to negatively charged lipids and may be involved in the differentiation of epithelial cells into mesenchymal cells. Increased expression of GAPR-1 in kidney may contribute to the development of fibrosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15464R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15464R-FITC
Lokale Artikelnummer::
BOSSBS-15464R-FITC
Beschreibung:
HERPUD1 is a includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12056R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12056R-CY5
Lokale Artikelnummer::
BOSSBS-12056R-CY5
Beschreibung:
Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. SR-3 is a ligand-gated ion channel, whereas all other known serotonin receptor subtypes are G protein-coupled receptors. SR-4 mediates widespread effects in central and peripheral nervous systems. SR-7 belongs to the superfamily of G protein-coupled receptors. The gene which encodes SR-7 maps to human chromosome 10q21-q24.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8411R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8411R-CY7
Lokale Artikelnummer::
BOSSBS-8411R-CY7
Beschreibung:
Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins that may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. GAPR-1 (Golgi-associated plant pathogenesis-related protein 1), also known as GLIPR2, is a 154 amino acid lipid anchor protein belonging to the CRISP family. GAPR-1 also shares similarity with the pathogenesis-related protein (PR) superfamily, and may play an important role in the immune system. Existing as a homodimer, GAPR-1 is highly expressed in lung and peripheral leukocytes with minor expression in liver and kidney. Containing a conserved sperm-coating protein (SCP) domain, GAPR-1 binds to negatively charged lipids and may be involved in the differentiation of epithelial cells into mesenchymal cells. Increased expression of GAPR-1 in kidney may contribute to the development of fibrosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8411R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8411R-CY5
Lokale Artikelnummer::
BOSSBS-8411R-CY5
Beschreibung:
Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins that may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. GAPR-1 (Golgi-associated plant pathogenesis-related protein 1), also known as GLIPR2, is a 154 amino acid lipid anchor protein belonging to the CRISP family. GAPR-1 also shares similarity with the pathogenesis-related protein (PR) superfamily, and may play an important role in the immune system. Existing as a homodimer, GAPR-1 is highly expressed in lung and peripheral leukocytes with minor expression in liver and kidney. Containing a conserved sperm-coating protein (SCP) domain, GAPR-1 binds to negatively charged lipids and may be involved in the differentiation of epithelial cells into mesenchymal cells. Increased expression of GAPR-1 in kidney may contribute to the development of fibrosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1459R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1459R-A680
Lokale Artikelnummer::
BOSSBS-1459R-A680
Beschreibung:
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1459R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1459R-A555
Lokale Artikelnummer::
BOSSBS-1459R-A555
Beschreibung:
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI6107)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6107
Lokale Artikelnummer::
PRSI6107
Beschreibung:
KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI29-966)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-966
Lokale Artikelnummer::
PRSI29-966
Beschreibung:
C8 beta is one of the three subunits that comprise the component 8 (C8) of the complement system. C8 participates in the formation of Membrane Attack Complex that results in the lysis of cells. Patients with C8B deficiency are prone to bacteria infection.C8 beta is one of the three subunits that comprise the component 8 (C8) of the complement system. C8 participates in the formation of Membrane Attack Complex that results in the lysis of cells. Patients with C8B deficiency are prone to bacteria infection. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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