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2-Methylbenzo[b]thiophen
Artikel-Nr:
(BOSSBS-3423R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3423R-CY7
Lokale Artikelnummer::
BOSSBS-3423R-CY7
Beschreibung:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(SIAL205664-25G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
205664-25G
Lokale Artikelnummer::
SIAL205664-25G
Beschreibung:
2-Acetyl-1-naphthol, Sigma-Aldrich®
VE:
1 * 25 g
Artikel-Nr:
(8.18247.9020)
Lieferant:
Merck
Hersteller-Artikelnummer::
8.18247.9020
Lokale Artikelnummer::
MERC8.18247.9020
Beschreibung:
Kupfer(II)chlorid zur Synthese, Sigma-Aldrich®
VE:
1 * 20 kg
Artikel-Nr:
(SIALA0783-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
A0783-1G
Lokale Artikelnummer::
SIALA0783-1G
Beschreibung:
N-Acetyl-L-proline, Sigma-Aldrich®
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-2987R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2987R-A680
Lokale Artikelnummer::
BOSSBS-2987R-A680
Beschreibung:
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10228R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10228R-CY5
Lokale Artikelnummer::
BOSSBS-10228R-CY5
Beschreibung:
The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10228R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10228R-A555
Lokale Artikelnummer::
BOSSBS-10228R-A555
Beschreibung:
The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6383R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6383R-A750
Lokale Artikelnummer::
BOSSBS-6383R-A750
Beschreibung:
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunisation induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localisation signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3423R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3423R-A680
Lokale Artikelnummer::
BOSSBS-3423R-A680
Beschreibung:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3423R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3423R-A647
Lokale Artikelnummer::
BOSSBS-3423R-A647
Beschreibung:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2903R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2903R
Lokale Artikelnummer::
BOSSBS-2903R
Beschreibung:
ARHI contains a highly conserved GTP-binding domain, a putative effector domain distinct from that of RAS and RAP proteins, and a C-terminal membrane localization motif. ARHI mRNA is detected in all normal breast and ovarian epithelial cell cultures tested, as well as in normal ovary, heart, liver, pancreas and brain however ARHI expression is down-regulated in breast and ovarian tumors. Reactivation of ARHI expression in breast cancer cells is associated with increased histone H3 acetylation and decreased lysine 9 methylation of histone H3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7618R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7618R-CY5
Lokale Artikelnummer::
BOSSBS-7618R-CY5
Beschreibung:
NOC2L is a transcriptional corepressor with inhibitor of histone acetyltransferase (INHAT) activity. NOC2L or NIR (Novel INHAT Repressor) is ubiquitously expressed throughout embryonic development and adulthood. It is a potent transcriptional corepressor that is not blocked by histone deacetylase inhibitors and is capable of silencing both basal and activator-driven transcription. NOC2L directly binds to nucleosomes and core histones and prevents acetylation by histone acetyltransferases, thus acting as a bona fide INHAT.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7618R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7618R-CY7
Lokale Artikelnummer::
BOSSBS-7618R-CY7
Beschreibung:
NOC2L is a transcriptional corepressor with inhibitor of histone acetyltransferase (INHAT) activity. NOC2L or NIR (Novel INHAT Repressor) is ubiquitously expressed throughout embryonic development and adulthood. It is a potent transcriptional corepressor that is not blocked by histone deacetylase inhibitors and is capable of silencing both basal and activator-driven transcription. NOC2L directly binds to nucleosomes and core histones and prevents acetylation by histone acetyltransferases, thus acting as a bona fide INHAT.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8450R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8450R-A750
Lokale Artikelnummer::
BOSSBS-8450R-A750
Beschreibung:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 <i>in vitro</i>; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5272R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5272R-A680
Lokale Artikelnummer::
BOSSBS-5272R-A680
Beschreibung:
MRG15 ia a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5272R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5272R-A647
Lokale Artikelnummer::
BOSSBS-5272R-A647
Beschreibung:
MRG15 ia a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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