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Dimethyl+bicyclo[2.1.1]hexane-1,4-dicarboxylate
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Dimethyl+bicyclo[2.1.1]hexane-1,4-dicarboxylate
Artikel-Nr:
(BOSSBS-11705R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11705R-FITC
Lokale Artikelnummer::
BOSSBS-11705R-FITC
Beschreibung:
AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8592R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8592R-CY5.5
Lokale Artikelnummer::
BOSSBS-8592R-CY5.5
Beschreibung:
Rad and Gem related GTP binding protein (REM) is a member of the RGK subfamily of Ras-like GTPases that also includes Rad, REM2 and Gem/Kir. REM is a phosphorylated protein that is highly expressed in cardiac muscle and moderately expressed in lung, kidney and skeletal muscle. REM associates with several 14-3-3 isoforms as well as with calmodulin in a calcium-dependent manner. REM mediates two distinct signal transduction pathways that regulate both cytoskeletal reorganization and voltage-gated calcium channel activity. REM decreases the current that passes through cardiac voltage-gated L-type Ca channels (Ca(V)). Overexpression of REM may result in the development of cytoplasmic processes, reorganization of the Actin cytoskeleton, reduction in focal adhesion size and an elongated or dendritic-like cell morphology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11705R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11705R-A488
Lokale Artikelnummer::
BOSSBS-11705R-A488
Beschreibung:
AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
Terpinolen (p-Mentha-1,4(8)-dien), Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
Terpinolen (p-Mentha-1,4(8)-dien), Sigma-Aldrich®
Artikel-Nr:
(USBI146729)
Lieferant:
US Biological
Hersteller-Artikelnummer::
146729
Lokale Artikelnummer::
USBI146729
Beschreibung:
Anti-NLRP14 Rabbit Polyclonal Antibody
VE:
1 * 100 µG
Lieferant:
COMBI-BLOCKS
Beschreibung:
Ethyl-2,4-dimethylthiazol-5-carboxylat
Artikel-Nr:
(BOSSBS-13324R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13324R-HRP
Lokale Artikelnummer::
BOSSBS-13324R-HRP
Beschreibung:
Rab proteins, a family of Ras-related small GTP-binding proteins, play a key role in regulating intracellular vesicle trafficking (1?). Rab GDP dissociation inhibitor (Rab GDI or GDI2) forms a soluble complex with Rab proteins and thereby prevents the exchange of GDP for GTP (1?). In mammals, there exist two major isoforms, Rab GDI alpha (also known as XAP-4) and Rab GDI beta (1,4). While the mammalian Rab GDI beta-genes are ubiquitously expressed, the Rab GDI ?genes are predominantly brain-specific (1). Since it is expressed predominantly in neural and sensory tissues, Rab GDI a may serve a specific function in neural signal transmission (5). The gene sequences for the Rab GDI proteins are extremely conserved in evolution, with substantial homology preserved across three eukaryotic kingdoms (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3773R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3773R-FITC
Lokale Artikelnummer::
BOSSBS-3773R-FITC
Beschreibung:
Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13727R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13727R-A750
Lokale Artikelnummer::
BOSSBS-13727R-A750
Beschreibung:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHB14 (Protocadherin beta 14) is a 798 amino acid protein that is one of 16 proteins in the protocadherin beta cluster. Unlike the alpha and gamma gene clusters whos genes are spliced to downstream constant region exons during transcription, members of the beta cluster (such as PCDHB14) do not use constant-region exons to produce mRNAs. As a result, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. Localized to the cell membrane, PCDHB14 is a single-pass type I membrane protein that contains six cadherin domains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12253R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12253R-HRP
Lokale Artikelnummer::
BOSSBS-12253R-HRP
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF219 (Zinc finger protein 219) is a 722 amino acid protein belonging to the Krüppel C2H2-type zinc-finger protein family. It is ubiquitously expressed and localizes to the nucleus. Containing 6 C2H2-type zinc fingers which function to bind DNA, ZNF219 is thought to be involved in transcriptional regulation. Specifically, ZNF219 has been identified as a transcriptional repressor that downregulates the transcription of the HMG-14 promoter.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9190R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9190R-A680
Lokale Artikelnummer::
BOSSBS-9190R-A680
Beschreibung:
Schlafen family members are preferentially expressed in lymphoid tissues and are differentially regulated during thymocyte maturation. Schlafen proteins function as suppressors of cell growth and are thought to play a role in the maintenance of T cell quiescence. The prototype member of the Schlafen family, Slfn1, is transcriptionally unregulated during thymocyte positive selection, and the induction of Slfn1 induces a G0/G1 arrest, suggesting that Slfn1 participates in the regulation of cell cycle and potentially acts as a determining factor for apoptosis. These proteins all contain a largely conserved core domain within the center of the sequence, and yet they are substantially diversified at the N terminus. Slfn14 (Schlafen family member 14) is a 912 amino acid protein belonging to the Schlafen family. Slfn14 exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 17q12.
VE:
1 * 100 µl
Lieferant:
Cayman Chemical
Beschreibung:
1,5,7-Triazabicyclo[4.4.0]dec-5-ene is a bicyclic guanidine base that can be used as a catalyst for a variety of base-mediated organic transformations, including Michael additions, Wittig reactions, Henry reactions, and transesterification reactions.
Artikel-Nr:
(BOSSBS-9190R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9190R-A647
Lokale Artikelnummer::
BOSSBS-9190R-A647
Beschreibung:
Schlafen family members are preferentially expressed in lymphoid tissues and are differentially regulated during thymocyte maturation. Schlafen proteins function as suppressors of cell growth and are thought to play a role in the maintenance of T cell quiescence. The prototype member of the Schlafen family, Slfn1, is transcriptionally unregulated during thymocyte positive selection, and the induction of Slfn1 induces a G0/G1 arrest, suggesting that Slfn1 participates in the regulation of cell cycle and potentially acts as a determining factor for apoptosis. These proteins all contain a largely conserved core domain within the center of the sequence, and yet they are substantially diversified at the N terminus. Slfn14 (Schlafen family member 14) is a 912 amino acid protein belonging to the Schlafen family. Slfn14 exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 17q12.
VE:
1 * 100 µl
Artikel-Nr:
(SIAL01432-10G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
01432-10G
Lokale Artikelnummer::
SIAL01432-10G
Beschreibung:
Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic food sweetener.
VE:
1 * 10 g
Artikel-Nr:
(BOSSBS-13508R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13508R-CY5
Lokale Artikelnummer::
BOSSBS-13508R-CY5
Beschreibung:
G2A (for G2 accumulation) is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress (1). G2A is predominantly expressed in hematopoietic tissues and in hematopoietic stem cells, and it is more highly detected in pro-B cells, while lower expression is observed in immature B cells and pre-B cells (1,2). G2A is expressed throughout T cell maturation, and it is further increased in response to T-cell activation (3). Ectopic expression of a G2A fusion protein in NIH/3T3 fibroblasts induces a cell cycle arrest that is consistent with a block at the G2/M transition (1,4). G2A is also able to attenuate the proliferative effects of Bcr-Abl, a chimeric tyrosine kinase oncogene, suggesting that G2A possesses anti-oncogenic properties (5). The amino acid sequence of G2A contains a destruction box motif that is consistently observed in cyclins, where it is required for ubiquitination and proteolytic degradation (6).
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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