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Dimethyl+bicyclo[2.1.1]hexane-1,4-dicarboxylate
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Dimethyl+bicyclo[2.1.1]hexane-1,4-dicarboxylate
Lieferant:
Honeywell Chemicals
Beschreibung:
Benzotriazol ≥99,0% zur amperometrischen Best. von Cu, Fluka™
Artikel-Nr:
(662-1237)
Lieferant:
Mettler - Toledo
Hersteller-Artikelnummer::
51344163
Lokale Artikelnummer::
METT51344163
Beschreibung:
pH electrodes with MultiPin™ connector.
VE:
1 * 1 ST
Artikel-Nr:
(EHERXA17000200AL)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
XA17000200AL
Lokale Artikelnummer::
EHERXA17000200AL
Beschreibung:
Organic Standard, Sulfathiazol 100 µg/ml in Acetonitril, Packung: Glasflasche
VE:
1 * 1 mL
Artikel-Nr:
(CMPLFC376731)
Lieferant:
CUSTOM MADE CHEMICALS LAB
Hersteller-Artikelnummer::
FC376731
Lokale Artikelnummer::
CMPLFC376731
Beschreibung:
Natriumchlorid 0.02 mol/l (0.02 N) in wässriger Lösung
VE:
1 * 2,5 L
Artikel-Nr:
(PRSI91-702)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-702
Lokale Artikelnummer::
PRSI91-702
Beschreibung:
Inositol Polyphosphate 1-Phosphatase (INPP1) is a member of the inositol monophosphatase family. INPP1 is widely expressed in tissues, with highest expression levels observed in the pancreas and kidney. INPP1 is inhibited by Li+. Removing the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. INPP1 is involved in signal transduction and phosphatidylinositol signaling pathway.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-046)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-046
Lokale Artikelnummer::
PRSI91-046
Beschreibung:
Human Chemokine (C-X-C Motif) Ligand 14 (CXCL14) is constitutively expressed in certain normal tissues but is reduced or absent from many established tumor cell lines and human cancers. CXCL14 is known to be a chemoattractant for monocyte and dendritic cells. CXCL14 inhibits angiogenesis and exhibits antimicrobial activities. Mature human and mouse CXCL14 differ by only 2 amino acid residues.
VE:
1 * 50 µG
Artikel-Nr:
(PROOCIL-PCB-144-C)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
CIL-PCB-144-C
Lokale Artikelnummer::
PROOCIL-PCB-144-C
Beschreibung:
2,2',3,4,5',6-Hexachlorbiphenyl (PCB Nr. 144)
VE:
1 * 5 mg
Lieferant:
Sigma-Aldrich
Beschreibung:
Antimon(III)kaliumoxidtartrat Hydrat, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-1135R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-CY3
Lokale Artikelnummer::
BOSSBS-1135R-CY3
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(SCOI285113130)
Lieferant:
SI Analytics
Hersteller-Artikelnummer::
285113130
Lokale Artikelnummer::
SCOI285113130
Beschreibung:
These low-maintenance electrodes are ideal for measuring in drinking water, industrial water and sewage range.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-3353R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3353R-CY3
Lokale Artikelnummer::
BOSSBS-3353R-CY3
Beschreibung:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3353R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3353R-CY5
Lokale Artikelnummer::
BOSSBS-3353R-CY5
Beschreibung:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.
VE:
1 * 100 µl
Artikel-Nr:
(NITRBOWB-12)
Lieferant:
Nitritex
Hersteller-Artikelnummer::
BOWB-12
Lokale Artikelnummer::
NITRBOWB-12
Beschreibung:
These cleanroom wipes are made of hydroentangled non woven polycellulose. They contain no optical brighteners or whitening agents and provide outstanding absorption properties.
VE:
1 * 2.100 ST
Lieferant:
Sigma-Aldrich
Beschreibung:
Ammoniumchlorid-[D4], Sigma-Aldrich®
Lieferant:
Alfa Aesar
Beschreibung:
(+)-cis-Diltiazem hydrochloride
Lieferant:
Mettler - Toledo
Beschreibung:
High performance electrodes combining robustness with state-of-the-art measurement technology. Fully traceable.
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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