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4-Chloro-2-methylbenzofuro[3,2-d]pyrimidine
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4-Chloro-2-methylbenzofuro[3,2-d]pyrimidine
Artikel-Nr:
(BOSSBS-1271R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1271R-A647
Lokale Artikelnummer::
BOSSBS-1271R-A647
Beschreibung:
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins(also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Isoform 2 seems to be proteolytically inactive. [CATALYTIC ACTIVITY] Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues. [SUBUNIT] Homotrimer. Interacts with MXI2. The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12359R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12359R-A488
Lokale Artikelnummer::
BOSSBS-12359R-A488
Beschreibung:
DMP-1 is a member of the small integrin ligand N-linked glycoprotein family. It is important for the mineralization of bone and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It is synthesized by preosteoblasts and contains a large number of acidic domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where it functions as a transcriptional regulator for osteoblast-specific gene activation and induces osteoblast differentiation. During osteoblast maturation, DMP-1 undergoes a conformational change and becomes phosphorylated by casein kinase II in response to an influx of calcium ions to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM) where it regulates the nucleation of hydroxyapatite and the formation of calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal fragments in the ECM of bone and dentin. The protein has also been identified in bone as a high molecular weight proteoglycan comprised of the N-terminal DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in hypomineralized bone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6909R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6909R-CY5.5
Lokale Artikelnummer::
BOSSBS-6909R-CY5.5
Beschreibung:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9700R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9700R-A647
Lokale Artikelnummer::
BOSSBS-9700R-A647
Beschreibung:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf43 gene product has been provisionally designated C20orf43 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9751R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9751R-CY3
Lokale Artikelnummer::
BOSSBS-9751R-CY3
Beschreibung:
Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD50 (ankyrin repeat domain 50) is a 1,429 amino acid phosphoprotein that contains nineteen ANK repeats. Conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly and mosquito, ANKRD50 is encoded by a gene that maps to human chromosome 4q28.1. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which encodes an expanded glutamine tract in cases of Huntington's disease, is located on chromosome 4. FGFR-3 is also encoded by a gene that maps to human chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also linked to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7023R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7023R-CY5.5
Lokale Artikelnummer::
BOSSBS-7023R-CY5.5
Beschreibung:
Produced by macrophages, IFN alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2583R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2583R
Lokale Artikelnummer::
BOSSBS-2583R
Beschreibung:
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8338R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8338R-HRP
Lokale Artikelnummer::
BOSSBS-8338R-HRP
Beschreibung:
Defects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1); also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS). It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in the first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in the second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP). HARP is a rare syndrome with many clinical similarities to NBIA1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8410R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8410R-A488
Lokale Artikelnummer::
BOSSBS-8410R-A488
Beschreibung:
GLCCI1, also known as TSSN1, GIG18 or FAM117C, is a 547 amino acid protein found in thymus and CD4(+)CD8(+) cells during specific stages of spermatogenesis in testis. Subject to phosphorylation, GLCCI1 is encoded by a gene located on human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7721R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7721R-A350
Lokale Artikelnummer::
BOSSBS-7721R-A350
Beschreibung:
NCAPG2 is 1 of 3 non-SMC subunits that define condensin II. Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4, but they contain different sets of non-SMC subunits. NCAPG2 is 1 of 3 non-SMC subunits that defines condensin II.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6223R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6223R-CY5
Lokale Artikelnummer::
BOSSBS-6223R-CY5
Beschreibung:
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9048R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9048R-CY7
Lokale Artikelnummer::
BOSSBS-9048R-CY7
Beschreibung:
TRPM6 is an essential ion channel and serine/threonine-protein kinase, and is crucial for magnesium homeostasis. TRPM6 also has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. The various isoforms of the type M6-kinase lack the ion channel region.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8236R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8236R-A555
Lokale Artikelnummer::
BOSSBS-8236R-A555
Beschreibung:
Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8031R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8031R-CY7
Lokale Artikelnummer::
BOSSBS-8031R-CY7
Beschreibung:
The function of COBLL1 is not known but there are five named isoforms produced by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0744R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0744R-CY3
Lokale Artikelnummer::
BOSSBS-0744R-CY3
Beschreibung:
Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) is a highly glycosylated protein expressed only in neutrophils and eosinophils in humans. The precise function of CEACAM8 remains unclear. As a member of the family of carcinoembryonic antigen (CEA), it may play a role in the interaction between granulocytes or between granulocytes and epithelial cells. Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4223R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4223R-FITC
Lokale Artikelnummer::
BOSSBS-4223R-FITC
Beschreibung:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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