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Essigsäure-[D1]
Artikel-Nr:
(BOSSBS-5846R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5846R
Lokale Artikelnummer::
BOSSBS-5846R
Beschreibung:
ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8546R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8546R-A680
Lokale Artikelnummer::
BOSSBS-8546R-A680
Beschreibung:
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localisation of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilisation. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8546R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8546R-A488
Lokale Artikelnummer::
BOSSBS-8546R-A488
Beschreibung:
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
VE:
1 * 100 µl
Lieferant:
COMBI-BLOCKS
Beschreibung:
Tetrahydropyran-4-essigsäure
Artikel-Nr:
(PRSI96-116)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-116
Lokale Artikelnummer::
PRSI96-116
Beschreibung:
CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.
CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.
VE:
1 * 100 µG
Lieferant:
FLUOROCHEM
Beschreibung:
(Methylthio)essigsäure
Lieferant:
Alfa Aesar
Beschreibung:
Europiumtriacetat Hydrat ≥99,999% (REO, Basis der Oxide der Metalle der seltenen Erden), REacton®
Lieferant:
BIONET RESEARCH
Beschreibung:
α-Oxothiophen-2-essigsäure
Lieferant:
Honeywell Chemicals
Beschreibung:
Essigsäure ≥99,99% (bezogen auf die Metalle der seltenen Erden)
Artikel-Nr:
(45741-1L)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
45741-1L
Lokale Artikelnummer::
HONC45741-1L
Beschreibung:
Essigsäure ≥98%, nach Ph. Eur. getestet, Fluka™
VE:
1 * 1 L
Artikel-Nr:
(SIAL555398-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
555398-1G
Lokale Artikelnummer::
SIAL555398-1G
Beschreibung:
(4-Benzyloxyphenyl)essigsäure, Sigma-Aldrich®
VE:
1 * 1 g
Lieferant:
Merck
Beschreibung:
Essigsäure 1 mol/l, EMPROVE® EXPERT für die biopharmazeutische Produktion, SAFC®
Lieferant:
Alfa Aesar
Beschreibung:
Certriacetat Hydrat ≥99,995% (Metall-Basis)
Artikel-Nr:
(1.37072.1000)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.37072.1000
Lokale Artikelnummer::
MERP1.37072.1000
Beschreibung:
Essigsäure ≥80%, EMPROVE® EXPERT für die biopharmazeutische Produktion
VE:
1 * 1 L
Artikel-Nr:
(BOSSBS-5846R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5846R-CY5.5
Lokale Artikelnummer::
BOSSBS-5846R-CY5.5
Beschreibung:
ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8546R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8546R-CY7
Lokale Artikelnummer::
BOSSBS-8546R-CY7
Beschreibung:
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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