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6-Chlorimidazo[1,2-a]pyridin+Hydrochlorid
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6-Chlorimidazo[1,2-a]pyridin+Hydrochlorid
Artikel-Nr:
(BOSSBS-15373R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15373R-CY5
Lokale Artikelnummer::
BOSSBS-15373R-CY5
Beschreibung:
GPCR TAS1R1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6854R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6854R-CY5.5
Lokale Artikelnummer::
BOSSBS-6854R-CY5.5
Beschreibung:
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6921R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6921R-CY5.5
Lokale Artikelnummer::
BOSSBS-6921R-CY5.5
Beschreibung:
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12321R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12321R-FITC
Lokale Artikelnummer::
BOSSBS-12321R-FITC
Beschreibung:
Tect3 is a 607 amino acid single-pass type I membrane protein that belongs to the tectonic family and exists as four alternatively spliced isoforms. Tect3 interacts with MKS1 and may be involved in apoptosis regulation. The gene that encodes Tect3 contains approximately 31,560 bases and maps to human chromosome 10q24.1. Spanning nearly 135 million base pairs and encoding nearly 1,200 genes, chromosome 10 makes up approximately 4.5% of the human genome. Several protein-coding genes, including those that encode chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, Cockayne syndrome, multiple endocrine neoplasia type 2 and porphyria. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12046R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12046R-FITC
Lokale Artikelnummer::
BOSSBS-12046R-FITC
Beschreibung:
The members of the G-protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. b-adrenergic bound to adrenaline activates adenylyl cyclase, while a2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the a2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1–7 (5HT1–7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3228R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3228R
Lokale Artikelnummer::
BOSSBS-3228R
Beschreibung:
Pro inflammatory cytokines activate the transcription factor NF kappa B by stimulating the activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF kappa B, at sites that trigger its ubiquitination and degradation. A large, cytokine responsive Ikappa B kinase (IKK) complex has been purified and the genes encoding 2 of its subunits have been cloned. These subunits, IKK alpha and Ikk beta, are protein kinases whose function is needed for NF kappa B activation by pro inflammatory stimuli. IKK is composed of similar amounts of IKK alpha, Ikk beta, which are differentially processed forms of a third subunit, IKK gamma. IKK gamma interacts preferentially with IKK beta and is required for the activation of the IKK complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12477R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12477R-FITC
Lokale Artikelnummer::
BOSSBS-12477R-FITC
Beschreibung:
The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain, which binds to phospholipids in a Ca2+-dependent manner, and a unique amino terminal region, which may confer binding specificity. The annexin family has been implicated as regulators of such diverse processes as ion-flux, endocytosis and exocytosis, and cellular adhesion. Two forms of Annexin XI, designated A and B, have been identified. Transfection of COS-7 cells with Annexin XI-A, but not Annexin XI-B, causes formation of Annexin XI-associated vesicles.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1243R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1243R-A488
Lokale Artikelnummer::
BOSSBS-1243R-A488
Beschreibung:
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11163R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11163R-FITC
Lokale Artikelnummer::
BOSSBS-11163R-FITC
Beschreibung:
Esophagin, also known as small proline-rich protein 3 (SPR3) or Cornifin ∫, belongs to the cornifin family of cornified-envelope structural proteins. It is expressed in mucosal epithelia such as esophagus and tongue and is strongly induced during epidermal keratinocyte differentiation. Due to its highly inducible nature, Esophagin is considered a marker of squamous differentiation. Esophagin serves as a cross-linking protein within the cornified cell envelope and may play a role in the maintenance of normal esophageal epithelial homeostasis. It shares significant homology with the related proteins, SPRR1 and SPRR2. Esophagin is typically not expressed in healthy human epithelium, but its expression is upregulated in numerous hyperproliferative disorders of the skin. Contrastly, its expression is dramatically downregulated in esophageal squamous cell carcinoma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13267R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13267R-A350
Lokale Artikelnummer::
BOSSBS-13267R-A350
Beschreibung:
GALK2 is important in the first step of the galactose metabolism pathway. GALK1, which belongs to the GHMP kinase family of proteins, is a crucial enzyme for galactose metabolism, specifically converting ?d-galactose to galactose 1-phosphate. Defects in the gene encoding GALK1 can cause galactosemia II, an autosomal recessive disorder characterized by congenital cataracts during infancy, often within the first two weeks of life. In the adult population, galactosemia II can cause presenile cataracts that are secondary to accumulation of galactitol in the lens of the eye. A second gene, GALK2, encodes an enzyme with greater activity against GalNAc than galactose. GALK2 has been implicated in the salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1528R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1528R-A680
Lokale Artikelnummer::
BOSSBS-1528R-A680
Beschreibung:
Attractin is a serum glycoprotein of 175 kDaand found in both membrane-bound and secreted forms as a result of alternative splicing. Both the secreted and membrane-bound forms of attractin may be involved in the development and maintenance of the central nervous system. Membrane-bound attractin is a co-receptor for Agouti, antagonist of melanocortin-1 receptor. Secreted attractin, expressed by activated T lymphocytes and modulates interactions between T cells and monocytes/macrophages, was examined as a potential marker of immune activity. Attractinmay be a component of a pathway for regulated protein turnover that also involves mahogunin, a wide-expressed E3 ubiquitinligase found at particularly high levels in the brain. Attractinwas considered as an extracellular target amenable for the development of obesity-regulating drugs, also.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5262R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5262R-HRP
Lokale Artikelnummer::
BOSSBS-5262R-HRP
Beschreibung:
Cyclin dependent kinases are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin dependent kinases is also regulated by the phosphorylation status, which is controlled by the antagonistic action of Wee1 kinase and CDC25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, and CDC25C. These three genes function at different phases of the cell cycle. Whereas CDC25A and CDC25B are expressed throughout the cell cycle, with peak expression in G1 for CDC25A and in both G1 S phase and G2 for CDC25B, CDC25C is predominantly expressed in G2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7613R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7613R-FITC
Lokale Artikelnummer::
BOSSBS-7613R-FITC
Beschreibung:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11327R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11327R-FITC
Lokale Artikelnummer::
BOSSBS-11327R-FITC
Beschreibung:
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11420R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11420R-FITC
Lokale Artikelnummer::
BOSSBS-11420R-FITC
Beschreibung:
Neuromedin U is a neuropeptide with high activity on smooth muscle. It is widely expressed in gastrointestinal systems and central nervous system (CNS). Peripheral activities of neuromedin U include smooth muscle stimulation, ion transport alterations in the gut and the regulation of local blood flow and adrenocortical function. Neuromedin U receptors 1 and 2 (NMUR1 and NMUR2) are multi-pass membrane proteins that belong to the G-protein coupled receptor 1 family of proteins. Both NMUR1 and NMUR2 act as receptors for the neuromedin U neuropeptide. NMUR1 is detected in peripheral organs, particularly in urogenital and gastrointestinal systems, with highest levels in testis. It’s expression in CNS is low, but the protein has been detected in cerebellum, hippocampus, dorsal root ganglia and spinal cord. NMUR2 is predominantly detected in central nervous system with highest levels detected in medulla oblongata, spinal cord and thalamus. It may also be detected in testis but has low levels of expression in peripheral tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3737R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3737R
Lokale Artikelnummer::
BOSSBS-3737R
Beschreibung:
Anti-PPARG Rabbit Polyclonal Antibody
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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