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2-Bromo-4-chloro-5-fluorobenzoic+acid
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2-Bromo-4-chloro-5-fluorobenzoic+acid
Artikel-Nr:
(PRSI33-169)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-169
Lokale Artikelnummer::
PRSI33-169
Beschreibung:
This cytokeratin 18 antibody reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 18 and 8 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-068)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-068
Lokale Artikelnummer::
PRSI33-068
Beschreibung:
This antibody recognises a protein of 36 kDa, identified as Cyclin D1. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms and a key cell cycle regulator. This antibody neutralizes the activity of Cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression. Cyclin D1 antibody is useful in identifying mantle cell lymphomas, which stain positive, from CLL/SLL and follicular lymphomas, which stain negative. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-431)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-431
Lokale Artikelnummer::
PRSI33-431
Beschreibung:
This mAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
VE:
1 * 100 µG
New Product
Lieferant:
Sigma-Aldrich
Beschreibung:
Cholsäure, Sigma-Aldrich®
Artikel-Nr:
(SPCMSO155-500GM)
Lieferant:
Spectrum Chemical
Hersteller-Artikelnummer::
SO155-500GM
Lokale Artikelnummer::
SPCMSO155-500GM
Beschreibung:
Sodium Chloride, Granular, USP is used in a variety of pharmaceutical formulations, to produce isotonic formulations, in tablet formulations and as an osmotic agent. This product is not sterile and not intended for use in the manufacture of injectable dosage forms, peritoneal dialysis solutions, hemodialysis solutions or hemofiltration solutions.
VE:
1 * 500 g
Lieferant:
Sigma-Aldrich
Beschreibung:
(R)-(-)-1,2-Propandiol, Sigma-Aldrich®
Lieferant:
MP Biomedicals
Beschreibung:
Trypan blue is a blue acid dye with a strong affinity for cellulose containing substrates such as cotton; less affinity for proteinaceous materials.
Artikel-Nr:
(BOSSBS-4985R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A680
Lokale Artikelnummer::
BOSSBS-4985R-A680
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Lieferant:
Honeywell Chemicals
Beschreibung:
Natriumchlorid 99,0-100,5% (Trockenmasse), Puriss., erfüllt analytische Spezifikationen von BP, Ph. Eur., USP (max. 0,00002% Al), Fluka™
Artikel-Nr:
(HONC66205-2.5L)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
66205-2.5L
Lokale Artikelnummer::
HONC66205-2.5L
Beschreibung:
Tetrahydrofuran, wasserfrei ≥99,9% Unstabilisiert für Anwendungen die einen niedrigen Wassergehalt benötigen <0.0025% H₂O, Riedel-de Haën™
VE:
1 * 2,5 L
Artikel-Nr:
(PRSI34-127)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-127
Lokale Artikelnummer::
PRSI34-127
Beschreibung:
This mAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(662-1584)
Lieferant:
Thermo Orion
Hersteller-Artikelnummer::
8103BNUWP
Lokale Artikelnummer::
ORIO8103BNUWP
Beschreibung:
Führen Sie präzise pH-Bestimmungen in Mikrovolumenproben mit dieser Universal-Kombinationselektrode mit Semi-Mikro-Spitze und Hochleistungs-Glasschaft durch. Im Vergleich zu herkömmlichen Elektroden liefert das bewährte ROSS-Referenzsystem eine höhere Messstabilität, eine schnellere Ansprechzeit sowie größere Genauigkeit und Präzision, wenn Sie Prüfproben messen möchten, deren Temperaturen schwanken oder von der Temperatur der Kalibrierpufferlösungen abweichen.
VE:
1 * 1 ST
Artikel-Nr:
(PRSI92-105)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-105
Lokale Artikelnummer::
PRSI92-105
Beschreibung:
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
VE:
1 * 50 µG
Artikel-Nr:
(662-0728)
Lieferant:
Thermo Orion
Hersteller-Artikelnummer::
8135BN
Lokale Artikelnummer::
ORIO8135BN
Beschreibung:
The ROSS combination flat surface pH electrodes measure pH of soft, moist surfaces — both solid and semi-solid — such as agar gel plates, meats, bread dough and similar samples. Compared to conventional electrodes, the proven ROSS reference system exhibits superior stability in measurements, faster response, greater accuracy and precision when measuring samples that vary in temperature or when calibrating in temperatures that differ from the samples.
VE:
1 * 1 ST
Artikel-Nr:
(GRSG602076)
Lieferant:
Greisinger
Hersteller-Artikelnummer::
602076
Lokale Artikelnummer::
GRSG602076
Beschreibung:
This meter is a simple handheld instrument for measuring pH, mV, temperature and relative humidity (0,0 to 70,0).
VE:
1 * 1 ST
Artikel-Nr:
(PRSI27-481)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-481
Lokale Artikelnummer::
PRSI27-481
Beschreibung:
The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu2+, Zn2+ and Cd2+. In mammals, MTF-1 serves at least two additional roles. First, targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration, revealing a stage-specific developmental role. Second, under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene placental growth factor (PIGF), an angiogenic protein.
VE:
1 * 100 µG
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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