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Methyl+2-chloro-6-(trifluoromethyl)isonicotinate
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Methyl+2-chloro-6-(trifluoromethyl)isonicotinate
Lieferant:
Thermo Scientific
Beschreibung:
Ethyl azidoacetate 25% in Toluol
Lieferant:
Thermo Scientific
Beschreibung:
1-Ethyl-2-pyrrolidon 98%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Ethyl methylsulphonylacetate 97%
Artikel-Nr:
(APOSOR475042-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR475042-1G
Lokale Artikelnummer::
APOSOR475042-1G
Beschreibung:
Ethyl 3-[(1S)-1-(prop-2-ynylamino)ethyl]benzoate hydrochloride
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-3050R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3050R-A488
Lokale Artikelnummer::
BOSSBS-3050R-A488
Beschreibung:
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3050R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3050R-A750
Lokale Artikelnummer::
BOSSBS-3050R-A750
Beschreibung:
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilisation. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilising p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
VE:
1 * 100 µl
Artikel-Nr:
(32559-1ML)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
32559-1ML
Lokale Artikelnummer::
SUPL32559-1ML
Beschreibung:
Organic Standard, Ethyl 4-hydroxybenzoate-ring-¹³C₆ solution
VE:
1 * 1 mL
Artikel-Nr:
(BOSSBS-5895R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5895R-FITC
Lokale Artikelnummer::
BOSSBS-5895R-FITC
Beschreibung:
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the Actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating Actin reorganization downstream of the Rho family of small GTPases. The protein homologs WAVE1 and WAVE2 regulate membrane ruffling by inducing the formation of Actin filament clusters in response to GTP binding and by activating Rac. They mediate Actin polymerization by cooperating with the Arp2/3 complex, thereby promoting the formation of Actin filaments. WAVE1, which is also designated SCAR (suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed, with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases with Actin and plays a role in the transduction of signals involving changes in cell shape, function or motility.
VE:
1 * 100 µl
Artikel-Nr:
(32186-10MG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
32186-10MG
Lokale Artikelnummer::
SUPL32186-10MG
Beschreibung:
Organic Standard, Oxolinic acid-(ethyl-d5)
VE:
1 * 10 mg
Lieferant:
Biotium
Beschreibung:
Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.
Lieferant:
Biotium
Beschreibung:
Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.
Artikel-Nr:
(BOSSBS-1091R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1091R-CY5.5
Lokale Artikelnummer::
BOSSBS-1091R-CY5.5
Beschreibung:
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8299R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8299R-CY7
Lokale Artikelnummer::
BOSSBS-8299R-CY7
Beschreibung:
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6976R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6976R-CY7
Lokale Artikelnummer::
BOSSBS-6976R-CY7
Beschreibung:
Phospholipase C beta 1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Its gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for its gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1091R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1091R-CY3
Lokale Artikelnummer::
BOSSBS-1091R-CY3
Beschreibung:
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4251R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4251R-CY5.5
Lokale Artikelnummer::
BOSSBS-4251R-CY5.5
Beschreibung:
PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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