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17-DMAG+hydrochloride
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17-DMAG+hydrochloride
Artikel-Nr:
(BOSSBS-11722R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11722R-CY5
Lokale Artikelnummer::
BOSSBS-11722R-CY5
Beschreibung:
Neural crest cell migration to the third and fourth pharyngeal pouches is a critical step in the structural formation of organs that are affected in DiGeorge syndrome. DGCR6 (DiGeorge syndrome critical region 6) is a nuclear protein that plays a role in neural crest cell migration and is located at the DiGeorge syndrome critical region (DGCR) on chromosome 22. Expressed ubiquitously with highest levels in heart, liver and skeletal muscle, DGCR6 shares high homology with the Drosophila gonadal (gdl) protein and with human Laminin ?1, both of which are involved in early tissue development. The gene encoding DGCR6, along with other DGCR genes, is deleted in DiGeorge syndrome; a developmental disorder characterized by improper facial, cardiac and palate formation. Upregulation of DGCR6 is implicated in lung and colon adenocarcinomas, as well as in Burkitt抯 lymphoma and lymphocytes transformed by EBV. Due to a duplication of the ancestral DGCR6 locus, there are two functional, highly homologous copies of the DGCR6 gene (designated DGCR6 and DGCR6L) on chromosome 22.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3345R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3345R-A680
Lokale Artikelnummer::
BOSSBS-3345R-A680
Beschreibung:
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Phosphorylates NEDD1. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylates both ECT2 and RACGAP1, and thereby stimulates their interaction that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3345R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3345R-A750
Lokale Artikelnummer::
BOSSBS-3345R-A750
Beschreibung:
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Phosphorylates NEDD1. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylates both ECT2 and RACGAP1, and thereby stimulates their interaction that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7949R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7949R-CY3
Lokale Artikelnummer::
BOSSBS-7949R-CY3
Beschreibung:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12188R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12188R-CY5
Lokale Artikelnummer::
BOSSBS-12188R-CY5
Beschreibung:
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5674R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5674R-CY5.5
Lokale Artikelnummer::
BOSSBS-5674R-CY5.5
Beschreibung:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3633R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3633R-CY5
Lokale Artikelnummer::
BOSSBS-3633R-CY5
Beschreibung:
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(8.24456.0500)
Lieferant:
Merck
Hersteller-Artikelnummer::
8.24456.0500
Lokale Artikelnummer::
MERC8.24456.0500
Beschreibung:
(2S,4R)-(-)-Ethyl-4-hydroxy-2-pyrrolidincarboxylate hydrochloride zur Synthese, Sigma-Aldrich®
VE:
1 * 500 mg
Artikel-Nr:
(BOSSBS-0076M-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0076M-A488
Lokale Artikelnummer::
BOSSBS-0076M-A488
Beschreibung:
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6090R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6090R-A350
Lokale Artikelnummer::
BOSSBS-6090R-A350
Beschreibung:
RBM5 (RNA binding motif protein 5) is a nuclear SR related RNA binding protein which specifically binds poly(G) RNA homopolymers in vitro. It modulates both apoptosis and the cell cycle, and retards tumor formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5089R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5089R-A647
Lokale Artikelnummer::
BOSSBS-5089R-A647
Beschreibung:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5089R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5089R-FITC
Lokale Artikelnummer::
BOSSBS-5089R-FITC
Beschreibung:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6909R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6909R-A750
Lokale Artikelnummer::
BOSSBS-6909R-A750
Beschreibung:
Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12527R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12527R-A488
Lokale Artikelnummer::
BOSSBS-12527R-A488
Beschreibung:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6909R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6909R-A680
Lokale Artikelnummer::
BOSSBS-6909R-A680
Beschreibung:
Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2686R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2686R-A555
Lokale Artikelnummer::
BOSSBS-2686R-A555
Beschreibung:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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