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2-(2-Fluorophenyl)-3-oxobutanenitrile
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2-(2-Fluorophenyl)-3-oxobutanenitrile
Artikel-Nr:
(BOSSBS-11952R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11952R-A647
Lokale Artikelnummer::
BOSSBS-11952R-A647
Beschreibung:
The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1549R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1549R-FITC
Lokale Artikelnummer::
BOSSBS-1549R-FITC
Beschreibung:
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5097R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5097R-CY3
Lokale Artikelnummer::
BOSSBS-5097R-CY3
Beschreibung:
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11770R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11770R-CY3
Lokale Artikelnummer::
BOSSBS-11770R-CY3
Beschreibung:
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-14441R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-14441R-A680
Lokale Artikelnummer::
BOSSBS-14441R-A680
Beschreibung:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3349R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3349R-A680
Lokale Artikelnummer::
BOSSBS-3349R-A680
Beschreibung:
postsynaptic density protein 95 is a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with DLG2. With DLG2 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2673R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2673R-A680
Lokale Artikelnummer::
BOSSBS-2673R-A680
Beschreibung:
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6459R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6459R-FITC
Lokale Artikelnummer::
BOSSBS-6459R-FITC
Beschreibung:
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12241R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12241R-CY3
Lokale Artikelnummer::
BOSSBS-12241R-CY3
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF704 is a 412 amino acid nuclear protein that contains one C2H2-type zinc finger. The gene encoding ZNF704 maps to human chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9519R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9519R-A350
Lokale Artikelnummer::
BOSSBS-9519R-A350
Beschreibung:
BPGM (2,3-bisphosphoglycerate mutase) is a 259 amino acid protein that belongs to the phosphoglycerate mutase family and exists as a homodimer that plays a crucial role in the regulation of hemoglobin oxygen. Specifically, BPGM catalyzes the conversion of 3-D-glyceroyl phosphate to 2,3-bisD-glycerate (2,3-BPG), a reaction that is essential for controlling the concentration of 2,3-BPG within the cell. The gene encoding BPGM maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Involvement in disease:Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD) . A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5805R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5805R-CY5
Lokale Artikelnummer::
BOSSBS-5805R-CY5
Beschreibung:
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8226R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8226R-CY5
Lokale Artikelnummer::
BOSSBS-8226R-CY5
Beschreibung:
FAM161B is a 647 amino acid protein that belongs to the FAM161 family. The gene that encodes FAM161B consists of approximately 16,413 bases and maps to human chromosome 14q24.3. Housing over 700 genes, chromosome 14 comprises nearly 3.5% of the human genome. Chromosome 14 encodes the Presenilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer’s disease. The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. An inversion of the long arm of chromosome 14 is thought to be involved in T-cell chronic lymphocytic leukemia (CLL), a cancer that affects T lymphocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5710R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5710R-HRP
Lokale Artikelnummer::
BOSSBS-5710R-HRP
Beschreibung:
BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor associated anti apoptotic protein by inhibiting the BID induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6152R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6152R-HRP
Lokale Artikelnummer::
BOSSBS-6152R-HRP
Beschreibung:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5158R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5158R-A350
Lokale Artikelnummer::
BOSSBS-5158R-A350
Beschreibung:
This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5453R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5453R-FITC
Lokale Artikelnummer::
BOSSBS-5453R-FITC
Beschreibung:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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