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INTEGRATED+DNA+TECHNOLOGIE
Artikel-Nr:
(BOSSBS-6124R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6124R-CY3
Lokale Artikelnummer::
BOSSBS-6124R-CY3
Beschreibung:
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6124R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6124R-CY5
Lokale Artikelnummer::
BOSSBS-6124R-CY5
Beschreibung:
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2980R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2980R-CY5.5
Lokale Artikelnummer::
BOSSBS-2980R-CY5.5
Beschreibung:
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2980R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2980R-CY3
Lokale Artikelnummer::
BOSSBS-2980R-CY3
Beschreibung:
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6124R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6124R-CY7
Lokale Artikelnummer::
BOSSBS-6124R-CY7
Beschreibung:
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6124R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6124R-A555
Lokale Artikelnummer::
BOSSBS-6124R-A555
Beschreibung:
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2980R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2980R-FITC
Lokale Artikelnummer::
BOSSBS-2980R-FITC
Beschreibung:
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2980R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2980R-CY7
Lokale Artikelnummer::
BOSSBS-2980R-CY7
Beschreibung:
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2980R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2980R-HRP
Lokale Artikelnummer::
BOSSBS-2980R-HRP
Beschreibung:
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2980R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2980R-A350
Lokale Artikelnummer::
BOSSBS-2980R-A350
Beschreibung:
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15497R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15497R-CY7
Lokale Artikelnummer::
BOSSBS-15497R-CY7
Beschreibung:
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6124R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6124R-A680
Lokale Artikelnummer::
BOSSBS-6124R-A680
Beschreibung:
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15497R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15497R-CY3
Lokale Artikelnummer::
BOSSBS-15497R-CY3
Beschreibung:
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15497R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15497R-A647
Lokale Artikelnummer::
BOSSBS-15497R-A647
Beschreibung:
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15497R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15497R-A750
Lokale Artikelnummer::
BOSSBS-15497R-A750
Beschreibung:
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2980R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2980R-A647
Lokale Artikelnummer::
BOSSBS-2980R-A647
Beschreibung:
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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