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Imidazo[1,2-b]pyridazin
Artikel-Nr:
(BOSSBS-12219R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12219R-A488
Lokale Artikelnummer::
BOSSBS-12219R-A488
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF426 (Zinc finger protein 426), also known as MGC2663, is a 554 amino acid protein that is thought to be involved in transcriptional regulation. Localized to the nucleus, ZNF426 contains one KRAB domain and 12 C2H2-type zinc fingers through which it may convey DNA, RNA and protein binding capabilities. Specifically, ZNF426 may interact with the viral protein KSHV ORF 50 and, through this interaction, may activate viral gene transcription.
VE:
1 * 100 µl
Lieferant:
HERAEUS
Beschreibung:
Dewargefäße und Kryolagerbehälter, CryoPlus™, Dreieckgestell, flüssige Phase, 1,5/2 ml Kapazität, nimmt 12 Kartons mit 81 Zellteiler, für 12 Boxen/Gestell, 660×198×191 mm, Für: CryoPlus 1
Artikel-Nr:
(734-1303)
Lieferant:
Corning
Hersteller-Artikelnummer::
352032
Lokale Artikelnummer::
BDAA352032
Beschreibung:
Falcon® snap caps are designed for use with 12×75 mm test tubes
VE:
1 * 2.000 ST
Lieferant:
EPPENDORF
Beschreibung:
Adapter, für 20 Röhrchen mit rundem Boden 1,2 - 5 ml, 2 Stück, Tisch-Zentrifuge
Artikel-Nr:
(PROOLGC2604)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
LGC2604
Lokale Artikelnummer::
PROOLGC2604
Beschreibung:
Benzil
VE:
1 * 500 mg
Artikel-Nr:
(FLUO001472-5G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
001472-5G
Lokale Artikelnummer::
FLUO001472-5G
Beschreibung:
(R)-(-)-2,2-Dimethyl-1,3-dioxolan-4-ylmethanol
VE:
1 * 5 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
Honeywell Chemicals
Beschreibung:
Ethylenglycol ≥99%, Reagenzqualität
Artikel-Nr:
(BOSSBS-11879R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11879R-A555
Lokale Artikelnummer::
BOSSBS-11879R-A555
Beschreibung:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. Leucine-rich glioma-inactivated protein 3 (LGI3), also known as LGI1-like protein 4 (LGIL4) or leucine-rich repeat LGI family member 3, is a 548 amino acid secretory protein. LGI3 contains five LRR repeats and seven EAR repeats. Widely expressed, with highest levels in brain and lung, LGI3 has been shown to colocalize with endocytosis-associated proteins, lipid raft markers, and Syntaxin. The gene encoding LGI3 maps to chromosome 8p21.3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13236R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13236R-A750
Lokale Artikelnummer::
BOSSBS-13236R-A750
Beschreibung:
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 (src kinase-associated phosphoprotein) and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn (13). SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells (13). SKAP55 contains an amino-terminal pleckstrin homology domain and a carboxy-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY) (4,5). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain (1,2). SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation (6). The human Fyb gene maps to chromosome 5p13.1 and encodes a 783 amino acid protein (7).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13281R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13281R-A647
Lokale Artikelnummer::
BOSSBS-13281R-A647
Beschreibung:
The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins (1,2). p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (3). Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations (3). Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold (4,5). The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity (6,7), and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9025R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9025R-A680
Lokale Artikelnummer::
BOSSBS-9025R-A680
Beschreibung:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. ISLR2 (immunoglobulin superfamily containing leucine-rich repeat 2), also known as LINX (leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein), is a 745 amino acid single-pass membrane protein that contains five LRR repeats, one Ig-like (immunoglobulin-like) domain, a LRRCT domain and one LRRNT domain. ISLR2 exists as a homomultimer and is essential for axon extension during neural development. The gene encoding ISLR2 maps to human chromosome 15q24.1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12475R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12475R-CY7
Lokale Artikelnummer::
BOSSBS-12475R-CY7
Beschreibung:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. ANKK1 (ankyrin repeat and kinase domain containing 1), also known as PKK2 or SGK288, is a 765 amino acid protein that belongs to the Ser/Thr protein kinase family and contains 12 ANK repeats and one protein kinase domain. Highly expressed in brain tissue and present in lower amounts in placenta and spinal cord, ANKK1 functions to catalyze the ATP-dependent phosphorylation of target proteins and is thought to play a role in alcohol and nicotine dependence. The gene encoding ANKK1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13657R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13657R
Lokale Artikelnummer::
BOSSBS-13657R
Beschreibung:
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9200R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9200R-FITC
Lokale Artikelnummer::
BOSSBS-9200R-FITC
Beschreibung:
Ig (immunoglobulin) superfamily members exhibit functional characteristics including immune responses, growth factor signaling and cell adhesion. IGSF10 (immunoglobulin superfamily, member 10), also known as Calvaria mechanical force protein 608 (CMF608), is a 2,623 amino acid secreted protein that contains an N-terminal signal peptide, six leucine-rich repeats (LRRs), and 12 immunoglobulin-like repeats. IGSF10 exists as multiple alternatively spliced isoforms, and is expressed in bone. Specifically, expression of IGSF10 is limited to mesenchymal osteochondroprogenitors with fibroblast-like morphology, where it is thought to be involved in the maintenance of the osteochondroprogenitor cells pool and its down-regulation precedes terminal differentiation. The gene encoding IGSF10 maps to chromosome 3, which comprises over 1,100 genes that include a chemokine receptor gene cluster as well as a variety of human cancer related loci.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9025R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9025R
Lokale Artikelnummer::
BOSSBS-9025R
Beschreibung:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. ISLR2 (immunoglobulin superfamily containing leucine-rich repeat 2), also known as LINX (leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein), is a 745 amino acid single-pass membrane protein that contains five LRR repeats, one Ig-like (immunoglobulin-like) domain, a LRRCT domain and one LRRNT domain. ISLR2 exists as a homomultimer and is essential for axon extension during neural development. The gene encoding ISLR2 maps to human chromosome 15q24.1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13281R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13281R-A680
Lokale Artikelnummer::
BOSSBS-13281R-A680
Beschreibung:
The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins (1,2). p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (3). Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations (3). Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold (4,5). The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity (6,7), and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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