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Imidazo[1,2-b]pyridazin
Artikel-Nr:
(PRSI90-302)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-302
Lokale Artikelnummer::
PRSI90-302
Beschreibung:
TLR11, an innate sensor for profilin (Toxoplasma gondii), is an intracellular receptor that resides in the endoplasmic reticulum. The 12 membrane-spanning endoplasmic reticulum-resident protein UNC93B1 interacts directly with TLR11 and regulates the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12, a previously uncharacterised TLR, also recognises profilin from Toxoplasma gondii. TLR12 is sufficient for recognition of profilin by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI90-287)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-287
Lokale Artikelnummer::
PRSI90-287
Beschreibung:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI91-236)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-236
Lokale Artikelnummer::
PRSI91-236
Beschreibung:
Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3455)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3455
Lokale Artikelnummer::
PRSI3455
Beschreibung:
Caspase-5 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1 beta and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1 beta. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI90-298)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-298
Lokale Artikelnummer::
PRSI90-298
Beschreibung:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI27-849)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-849
Lokale Artikelnummer::
PRSI27-849
Beschreibung:
TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI76-076)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-076
Lokale Artikelnummer::
PRSI76-076
Beschreibung:
The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.
VE:
1 * 0,1 mg
Lieferant:
Sigma-Aldrich
Beschreibung:
DL-Tryptophan, Sigma-Aldrich®
Artikel-Nr:
(PRSI3447)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3447
Lokale Artikelnummer::
PRSI3447
Beschreibung:
Caspase-2 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1 beta and IL-18. Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis. Caspase-2 has two major isoforms; overexpression on the long form results in apoptosis while that of the short form suppresses cell death.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI27-850)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-850
Lokale Artikelnummer::
PRSI27-850
Beschreibung:
TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX5 is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in TBX5 have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for TBX5.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI7421)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7421
Lokale Artikelnummer::
PRSI7421
Beschreibung:
Bim EL Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1,2).
VE:
1 * 100 µG
Artikel-Nr:
(665-0283)
Lieferant:
Thermo Orion
Hersteller-Artikelnummer::
VSTAR00
Lokale Artikelnummer::
ORIOVSTAR00
Beschreibung:
Dieses Messgerät bietet austauschbare Messmodule, mit denen mehrere Benutzer vier separate Kanäle an ihre spezifischen Anforderungen anpassen können.
VE:
1 * 1 ST
Artikel-Nr:
(PROOBP618)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
BP618
Lokale Artikelnummer::
PROOBP618
Beschreibung:
Cholsäure
VE:
1 * 100 mg
Artikel-Nr:
(PRSI28-508)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-508
Lokale Artikelnummer::
PRSI28-508
Beschreibung:
The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. Anti-PGBD3 belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. Anti-PGBD3 overlaps with the ERCC6 gene on chromosome 10, and pseudogenes of this locus have been found on chromosomes 4, 5 and 12.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI33-461)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-461
Lokale Artikelnummer::
PRSI33-461
Beschreibung:
Recognises a 12-14 kDa doublet of Calgranulin A/B (also known as S100A8/A9 or MRP-8/14); expressed by granulocytes, monocytes and by tissue macrophages. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of this protein is associated with the disease cystic fibrosis. This mAb reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and has been shown as an important marker for identifying macrophages in tissue sections.
VE:
1 * 100 µG
Artikel-Nr:
(135-1738)
Lieferant:
HERAEUS
Hersteller-Artikelnummer::
51029702
Lokale Artikelnummer::
HERA51029702
Beschreibung:
Die Heraguard™ ECO Werkbänke sind ideal für alle Anwendungen im Labor, bei denen der Produktschutz im Vordergrund steht. Dank ihrer Gleichstrommotoren verbrauchen sie weniger Energie und geben damit auch weniger Wärme in die Laborumgebung ab.
VE:
1 * 1 ST
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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