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Imidazo[1,2-b]pyridazin
Artikel-Nr:
(PRSI7001)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7001
Lokale Artikelnummer::
PRSI7001
Beschreibung:
RGS22 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.
VE:
1 * 100 µG
Artikel-Nr:
(SIALA93607-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
A93607-1G
Lokale Artikelnummer::
SIALA93607-1G
Beschreibung:
1H-Imidazo[4,5-b]pyridin 99% 1 * 1 g
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-11607R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11607R-A488
Lokale Artikelnummer::
BOSSBS-11607R-A488
Beschreibung:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRC54 (leucine-rich repeat-containing protein 54), also known as tsukushin, TSKU or E2-induced gene 4 protein (E2IG4), is a 353 amino acid secreted protein that likely localizes to the cell membrane and extracellular compartments. Involved in extracellular secretion and intracellular transport, LRRC54 can be induced by 17-beta-estradiol. Containing nine LRR repeat and a cleavable signal peptide, the gene encoding LRRC54 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI5847)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5847
Lokale Artikelnummer::
PRSI5847
Beschreibung:
SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart (1,2). Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Snail, and Slug.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-13140R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13140R-A350
Lokale Artikelnummer::
BOSSBS-13140R-A350
Beschreibung:
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
VE:
1 * 100 µl
Artikel-Nr:
(PRSI34-131)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-131
Lokale Artikelnummer::
PRSI34-131
Beschreibung:
Recognises a protein of 42-46 kDa, identified as MAGE-1. This mAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-13140R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13140R-A488
Lokale Artikelnummer::
BOSSBS-13140R-A488
Beschreibung:
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11607R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11607R-A680
Lokale Artikelnummer::
BOSSBS-11607R-A680
Beschreibung:
The leucine-rich (LRR) repeat is a 20 to 30 amino acid motif that forms a hydrophobic / horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRC54 (leucine-rich repeat-containing protein 54), also known as tsukushin, TSKU or E2-induced gene 4 protein (E2IG4), is a 353 amino acid secreted protein that likely localizes to the cell membrane and extracellular compartments. Involved in extracellular secretion and intracellular transport, LRRC54 can be induced by 17-beta-estradiol. Containing nine LRR repeat and a cleavable signal peptide, the gene encoding LRRC54 maps to human chromosome 11, which houses over 1400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13140R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13140R-A647
Lokale Artikelnummer::
BOSSBS-13140R-A647
Beschreibung:
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
VE:
1 * 100 µl
Artikel-Nr:
(AMBDA149516-1G)
Lieferant:
AMBEED
Hersteller-Artikelnummer::
A149516-1G
Lokale Artikelnummer::
AMBDA149516-1G
Beschreibung:
3H-IMIDAZO[4,5-B]PYRIDINE-5-CARBOXYLIC A 1 * 1 g
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PHBLPBZ2836-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PBZ2836-1G
Lokale Artikelnummer::
PHBLPBZ2836-1G
Beschreibung:
ETHYL IMIDAZO[1,5-A]PYRIDINE-3-CARBOXYLA 1 * 1 g
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PHBLPBU0421-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PBU0421-1G
Lokale Artikelnummer::
PHBLPBU0421-1G
Beschreibung:
7-BROMO-6-METHOXY-IMIDAZO[1,5-A]PYRIDINE 1 * 1 g
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PHBLPBU6273-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PBU6273-1G
Lokale Artikelnummer::
PHBLPBU6273-1G
Beschreibung:
5-BROMO-6-METHYL-IMIDAZO[1,5-A]PYRIDINE 1 * 1 g
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PHBLPBN2011655-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PBN2011655-1G
Lokale Artikelnummer::
PHBLPBN2011655-1G
Beschreibung:
ETHYL IMIDAZO[1,5-A]PYRIDINE-1-CARBOXYLA 1 * 1 g
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PHBLPBU0554-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PBU0554-1G
Lokale Artikelnummer::
PHBLPBU0554-1G
Beschreibung:
5-BROMO-1H-IMIDAZO[4,5-B]PYRAZINE 1 * 1 g
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PHBLPBYS1155-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PBYS1155-1G
Lokale Artikelnummer::
PHBLPBYS1155-1G
Beschreibung:
2-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE 1 * 1 g
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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