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K+LINE+LOGISTIS+(USA)+INC
Artikel-Nr:
(PRSI34-193)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-193
Lokale Artikelnummer::
PRSI34-193
Beschreibung:
A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(BOSSBS-10366R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10366R-CY7
Lokale Artikelnummer::
BOSSBS-10366R-CY7
Beschreibung:
Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10366R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10366R-HRP
Lokale Artikelnummer::
BOSSBS-10366R-HRP
Beschreibung:
Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2609R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2609R-CY7
Lokale Artikelnummer::
BOSSBS-2609R-CY7
Beschreibung:
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI2233)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2233
Lokale Artikelnummer::
PRSI2233
Beschreibung:
Survivin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI2157)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2157
Lokale Artikelnummer::
PRSI2157
Beschreibung:
DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa B and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI34-194)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-194
Lokale Artikelnummer::
PRSI34-194
Beschreibung:
A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-837)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-837
Lokale Artikelnummer::
PRSI33-837
Beschreibung:
A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI3515)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3515
Lokale Artikelnummer::
PRSI3515
Beschreibung:
PTEN Antibody: PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a dual-specificity phosphatase (with both protein and lipid phosphatase activity) first identified as a tumor suppressor gene. PTEN indirectly activates the AKT/PI3K pathway, an important signaling pathway for cell growth and proliferation by keeping levels of the second messenger PIP3 low, thereby preventing phosphoinositide-dependent kinase-1 (PDK-1) from phosphorylating and activating AKT. Expression of wild-type PTEN causes growth arrest in many cancer cell lines, but expression of a PTEN protein containing a mutation that blocks its lipid phosphatase activity failed to suppress growth of glioma cell lines suggesting that the tumor suppressive effect of PTEN is mediated solely by its lipid phosphatase activity. Other activities include the inhibition of insulin stimulated MAPK activation by blocking the insulin-receptor substrate (IRS)-1 phosphorylation and assembly of the IRS-1/Grb2/Sos complex.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-2053R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2053R-CY5.5
Lokale Artikelnummer::
BOSSBS-2053R-CY5.5
Beschreibung:
May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2053R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2053R-CY3
Lokale Artikelnummer::
BOSSBS-2053R-CY3
Beschreibung:
May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI33-688)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-688
Lokale Artikelnummer::
PRSI33-688
Beschreibung:
It recognises a protein of 75 kDa, identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-512)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-512
Lokale Artikelnummer::
PRSI33-512
Beschreibung:
A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with RituximAb (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-601)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-601
Lokale Artikelnummer::
PRSI33-601
Beschreibung:
Adipophilin, also called Perilipin 2, ADRP (Adipose differentiation related protein), and PLIN2, belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material and maybe involved in development and maintenance of adipose tissue. It is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-587)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-587
Lokale Artikelnummer::
PRSI33-587
Beschreibung:
Adipophilin, also called Perilipin 2, ADRP (Adipose differentiation related protein), and PLIN2, belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material and maybe involved in development and maintenance of adipose tissue. It is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI38-213)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
38-213
Lokale Artikelnummer::
PRSI38-213
Beschreibung:
A novel cytokine related to IL2 and IL15 was recently identified and designated IL21. IL21 has been found to be a powerful growth factor for naive B cells. The receptor for IL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessary for the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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