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Artikel-Nr: (PRSI91-830)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 91-830

Lokale Artikelnummer:: PRSI91-830

Beschreibung: Cytokine are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteine. CCL24 diaplays the chemotactic for resting T-lymphocytes and eosinophils. CCL24 has lower chemotatic activity for neutrophils, none for monocytes and activated lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell lines.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI28-748)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 28-748

Lokale Artikelnummer:: PRSI28-748

Beschreibung: KLF2/Lung Kruppel-like factor (LKLF) functions as a negative regulator of adipocyte differentiation. KLF2 is highly expressed in adipose tissue, and studies in cell lines and primary cells demonstrate that KLF2 is expressed in preadipocytes but not mature adipocytes.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI91-536)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 91-536

Lokale Artikelnummer:: PRSI91-536

Beschreibung: Glioma Pathogenesis-Related Protein 1 (GLIPR1) is a member of the CRISP family. It is a single-pass membrane protein with 266 amino acids. GLIPR1 is highly expressed in the lung and kidney and lowly expressed in the heart and liver. It is also highly expressed in cell lines that are derived from nervous system tumors arising from glia; conversely, it is lowly expressed in non-glial-derived nervous system tumor cell lines. GLIPR1 is only expressed in brain tumor glioblastoma multiforme/astrocytoma and not expressed in other nervous system tumors nor normal adult or fetal tissues.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI28-032)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 28-032

Lokale Artikelnummer:: PRSI28-032

Beschreibung: ASH2L plays a role in hematopoiesis and is associated with some special kinds of leukemia. The amount of ASH2L transcripts is extremely high in fetal liver, testis, and leukemia cell lines with erythroid and megakaryocytic potential.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI76-864)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 76-864

Lokale Artikelnummer:: PRSI76-864

Beschreibung: The BV13 monoclonal antibody specifically reacts with mouse CD144 (VE-Cadherin), a 120 kDa type II Cadherin. CD144 is a hemophilic adhesion molecule of the endothelial cell line essential to maintaining cell layer integrity. It is involved in cell growth inhibition, migration, and survival.

VE: 1 * 0,025 mg

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Artikel-Nr: (PRSI92-285)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-285

Lokale Artikelnummer:: PRSI92-285

Beschreibung: Lymphocyte cytosolic protein 2（LCP2）contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification. Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

VE: 1 * 50 µG

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Artikel-Nr: (PRSIXW-7955)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: XW-7955

Lokale Artikelnummer:: PRSIXW-7955

Beschreibung: FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
SUBUNIT: LSm subunits form a heteromer with a dougnut shape.
SIMILARITY: Belongs to the snRNP Sm proteins family.
SUBCELLULAR LOCATION: Nuclear (Potential).
TISSUE SPECIFICITY: Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI49-544)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 49-544

Lokale Artikelnummer:: PRSI49-544

Beschreibung: Found to be homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte. Mutations are also associated with pancreatic adenocarcinoma.

VE: 1 * 50 µl

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Artikel-Nr: (PRSIXP-5103)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: XP-5103

Lokale Artikelnummer:: PRSIXP-5103

Beschreibung: APRIL (A PRoliferation Inducing Ligand) a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. Members of the TNF superfamily regulate immune responses and induce apoptosis.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI29-998)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 29-998

Lokale Artikelnummer:: PRSI29-998

Beschreibung: GPNMB is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential.The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI7269)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 7269

Lokale Artikelnummer:: PRSI7269

Beschreibung: PRKCDBP Antibody: The protein kinase C delta (PKC-δ) binding protein (PRKCDBP), also known as cavin-3, is a member of the cavin family of proteins that are involved in caveolin formation and regulation. PRKCDBP was initially identified in a screen of cultured cell lines for proteins that were strongly induced by serum starvation. Studies indicate that PRKCDBP binds not only to PKC-δ but also to caveolin-1 and helps regulate caveolin traffic and function. Similar to other members of the cavin family, the expression of PRKCDBP was found to be down-regulated in various cancer cell lines, suggesting a possible tumor suppressor function of PRKCDBP.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI96-682)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 96-682

Lokale Artikelnummer:: PRSI96-682

Beschreibung: Secreted and transmembrane protein 1 (SECTM1) is also known as Protein K-12, which is belongs to the SECTM family, which is Inducted by IFNG/IFN-gamma (at protein level). SECTM1 is detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. SECTM1 may be involved in thymocyte signaling.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI26-405)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 26-405

Lokale Artikelnummer:: PRSI26-405

Beschreibung: MDM1 is a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles and is amplified in the mouse transformed 3T3 cell line, and the protein is able to bind to p53. This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles and is amplified in the mouse transformed 3T3 cell line, and the protein is able to bind to p53. In mouse several transcripts have been described for this gene which result from alternative polyadenylation, splicing and exon usage.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI76-863)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 76-863

Lokale Artikelnummer:: PRSI76-863

Beschreibung: The BV13 monoclonal antibody specifically reacts with mouse CD144 (VE-Cadherin), a 120 kDa type II Cadherin. CD144 is a hemophilic adhesion molecule of the endothelial cell line essential to maintaining cell layer integrity. It is involved in cell growth inhibition, migration, and survival.

VE: 1 * 0,1 mg

New Product Sale

Artikel-Nr: (PRSI5705)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 5705

Lokale Artikelnummer:: PRSI5705

Beschreibung: TINP1 Antibody: TINP1 (TGF-beta inducible nuclear protein 1), also known as NSA2 (Nop seven-associated 2), is a highly conserved nucleolar protein essential for large ribosomal subunit biogenesis. NSA2 is broadly expressed in human tissues and cultured cell lines, and located in the nucleolus of the cell. It is thought to be involved in cell proliferation and cell cycle regulation.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI30-441)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 30-441

Lokale Artikelnummer:: PRSI30-441

Beschreibung: NAT6 belongs to the acetyltransferase family. It contains 1 N-acetyltransferase domain. NAT6 seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. It may act as a tumor suppressor. Defects in NAT6 are found in non-small cell lung cancer (NSCLC) cell lines.

VE: 1 * 50 µG

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