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Artikel-Nr: (PRSI91-046)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 91-046

Lokale Artikelnummer:: PRSI91-046

Beschreibung: Human Chemokine (C-X-C Motif) Ligand 14 (CXCL14) is constitutively expressed in certain normal tissues but is reduced or absent from many established tumor cell lines and human cancers. CXCL14 is known to be a chemoattractant for monocyte and dendritic cells. CXCL14 inhibits angiogenesis and exhibits antimicrobial activities. Mature human and mouse CXCL14 differ by only 2 amino acid residues.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI5849)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 5849

Lokale Artikelnummer:: PRSI5849

Beschreibung: SCRN1 Antibody: SCRN1 was first identified as a cytosolic protein that is involved in the regulation of exocytosis from peritoneal mast cells. More recent studies have shown that SCRN1 expression is upregulated in gastric cancer cell lines and may possess epitopes that could function as tumor-associated antigens, potentially providing targets for cancer vaccines in the treatment of gastric cancers. Another report indicates that decreased expression of SCRN1 via RNAi expression resulted in significantly lower rates of cell growth in colorectal cancer cell lines, and increased SCRN1 expression in patients with colorectal cancer correlated with poor prognosis, suggesting that SCRN1 may also be involved in the regulation of cell growth and might be useful as a prognostic tool.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI26-244)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 26-244

Lokale Artikelnummer:: PRSI26-244

Beschreibung: Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI92-221)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-221

Lokale Artikelnummer:: PRSI92-221

Beschreibung: EIF5A2 is a member of the eIF-5A family. It is a 153 amino acids protein that in humans is encoded by the EIF5A2 gene. EIF5A2 is expressed in ovarian and colorectal cancer cell lines and highly expressed in testis.It has an important function at the level of mRNA turnover and mediates effects of polyamines on neuronal process extension and survival. It plays an important role in brain development and function, and in skeletal muscle stem cell differentiation.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI33-442)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 33-442

Lokale Artikelnummer:: PRSI33-442

Beschreibung: Recognises 78 kDa moesin protein. Moesin, a member of the talin-4.1 superfamily, is a linking protein of the sub-membranous actin cytoskeleton. It is expressed in variable amounts in cells of different phenotypes such as macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. The ERM proteins, ezrin, radixin, and moesin are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures, and are highly homologous, both in protein sequence and in functional activity, with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI26-405)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 26-405

Lokale Artikelnummer:: PRSI26-405

Beschreibung: MDM1 is a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles and is amplified in the mouse transformed 3T3 cell line, and the protein is able to bind to p53. This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles and is amplified in the mouse transformed 3T3 cell line, and the protein is able to bind to p53. In mouse several transcripts have been described for this gene which result from alternative polyadenylation, splicing and exon usage.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI76-863)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 76-863

Lokale Artikelnummer:: PRSI76-863

Beschreibung: The BV13 monoclonal antibody specifically reacts with mouse CD144 (VE-Cadherin), a 120 kDa type II Cadherin. CD144 is a hemophilic adhesion molecule of the endothelial cell line essential to maintaining cell layer integrity. It is involved in cell growth inhibition, migration, and survival.

VE: 1 * 0,1 mg

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Artikel-Nr: (PRSI5705)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 5705

Lokale Artikelnummer:: PRSI5705

Beschreibung: TINP1 Antibody: TINP1 (TGF-beta inducible nuclear protein 1), also known as NSA2 (Nop seven-associated 2), is a highly conserved nucleolar protein essential for large ribosomal subunit biogenesis. NSA2 is broadly expressed in human tissues and cultured cell lines, and located in the nucleolus of the cell. It is thought to be involved in cell proliferation and cell cycle regulation.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI3409)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 3409

Lokale Artikelnummer:: PRSI3409

Beschreibung: XAF-1 Antibody: XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death. XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines. Both IFN-alpha2 and IFN-beta can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI3091)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 3091

Lokale Artikelnummer:: PRSI3091

Beschreibung: AID Antibody: Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI33-174)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 33-174

Lokale Artikelnummer:: PRSI33-174

Beschreibung: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MUC18 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MUC18/CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI34-157)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 34-157

Lokale Artikelnummer:: PRSI34-157

Beschreibung: Recognises a protein of 21 kDa, identified as the Bax protein. This mAb is highly specific to Bax and shows no cross-reaction with Bcl-2 or Bcl-X protein. Bcl-2 blocks cell death following a variety of stimuli. Bax has extensive amino acid homology with Bcl-2 and it homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.

VE: 1 * 100 µG

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Artikel-Nr: (PRSIXP-5103BT)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: XP-5103BT

Lokale Artikelnummer:: PRSIXP-5103BT

Beschreibung: APRIL (A PRoliferation Inducing Ligand) a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. Members of the TNF superfamily regulate immune responses and induce apoptosis.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI4211)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 4211

Lokale Artikelnummer:: PRSI4211

Beschreibung: CDKN2A Antibody: The CDKN2A locus gives rise to 2 distinct transcripts from different promoters. The transcripts have been designated p16(INK4A) and p14(ARF). This chromosomal region undergoes a number of inversions, translocations, heterozygous deletions, and homozygous deletions in a variety of malignant cell lines including those from glioma, non-small cell lung cancer, leukemia, and melanoma. Deletion of the region containing CDKN2A is found in more than half of all melanoma cell lines. Conversely, transfection of CDKN2A suppressed the growth of two independent mesothelioma cell lines, suggesting that inactivation of the CDKN2 gene is an essential step in the etiology of malignant mesotheliomas. CDKN2A induces a G1 cell cycle arrest by inhibiting the phosphorylation of the Rb protein by the cyclin-dependent kinases CDK4 and CDK6. CDKN2A is expressed as at least three distinct isoforms.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI5631)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 5631

Lokale Artikelnummer:: PRSI5631

Beschreibung: BCAS4 Antibody: The Breast carcinoma amplified sequence (BCAS4) gene is localized to 20q13, a region that is often amplified in breast cancers. It was isolated by the cloning of a highly overexpressed 1.3 kb transcript from the fusion of the last two exons of the BCAS3 and BCAS4 genes. This BCAS3-BCAS4 fusion transcript is only found in the MCF7 cell line, but the BCAS4 gene is also overexpressed in nine of thirteen breast cancer cell lines. The role of BCAS4 is unknown but its mRNA is highly expressed in thymus, spleen, kidney, brain, and placenta, suggesting BCAS4 plays other roles in multiple tissues.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI33-868)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 33-868

Lokale Artikelnummer:: PRSI33-868

Beschreibung: EpCAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. [UniProt].

VE: 1 * 100 µG

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