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K+LINE+LOGISTIS+(USA)+INC
Artikel-Nr:
(BOSSBS-4221R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4221R-A647
Lokale Artikelnummer::
BOSSBS-4221R-A647
Beschreibung:
Involved in the conversion of lanosterol to cholesterol.Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4221R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4221R-A350
Lokale Artikelnummer::
BOSSBS-4221R-A350
Beschreibung:
Involved in the conversion of lanosterol to cholesterol.Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1026R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1026R-CY5.5
Lokale Artikelnummer::
BOSSBS-1026R-CY5.5
Beschreibung:
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1026R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1026R-CY7
Lokale Artikelnummer::
BOSSBS-1026R-CY7
Beschreibung:
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI32-175)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
32-175
Lokale Artikelnummer::
PRSI32-175
Beschreibung:
IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI5727)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5727
Lokale Artikelnummer::
PRSI5727
Beschreibung:
APC5 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC5 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC5, it is thought that APC5 associates with other APC/C components APC1, APC4, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4685)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4685
Lokale Artikelnummer::
PRSI4685
Beschreibung:
Nanos1 Antibody: Nanos1 is one of three known mammalian homologs to the Drosophila gene nanos. Nanos1 is an RNA-binding protein containing a zinc-finger motif and is expressed in the developing nervous system and continues in the adult brain. Interestingly, unlike mice deficient in either nanos2 or nanos3, mice lacking the nanos1 gene develop normally with no sign of abnormalities. Recently it has been found that expression of nanos1 mRNA is down-regulated by E-cadherin in a human breast cancer cell line and the amino-terminal domain on Nanos1 interacts with the E-cadherin-binding protein p120ctn. Furthermore, overexpression of Nanos1 in human colorectal DLD1 cancer cells functionally abolished cell-cell adhesion, allowing the cancer cells to develop strong migratory and invasive properties. These results suggest that targeting Nanos1 might prove an effective strategy in the treatment of E-cadherin-negative tumors.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI90-431)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-431
Lokale Artikelnummer::
PRSI90-431
Beschreibung:
Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumour cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI50-269)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
50-269
Lokale Artikelnummer::
PRSI50-269
Beschreibung:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gamma;s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKCepsilon regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7513R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7513R-CY5.5
Lokale Artikelnummer::
BOSSBS-7513R-CY5.5
Beschreibung:
BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7513R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7513R-CY7
Lokale Artikelnummer::
BOSSBS-7513R-CY7
Beschreibung:
BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6114R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6114R-CY7
Lokale Artikelnummer::
BOSSBS-6114R-CY7
Beschreibung:
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7513R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7513R-A488
Lokale Artikelnummer::
BOSSBS-7513R-A488
Beschreibung:
BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8324R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8324R-A647
Lokale Artikelnummer::
BOSSBS-8324R-A647
Beschreibung:
Headpin is a skin-specific, UV-repressible serine proteinase inhibitor (serpin) belonging to the ovalbumin serpin family. Headpin is abundant in the human keratinocyte cell line HaCaT, and in lesional keratinocytes from psoriatic skin. Headpin downregulation occurs in squamous cell carcinoma of the oral cavity and in squamous cell carcinoma cell lines of the head and neck.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5957R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5957R-CY5.5
Lokale Artikelnummer::
BOSSBS-5957R-CY5.5
Beschreibung:
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5957R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5957R-CY5
Lokale Artikelnummer::
BOSSBS-5957R-CY5
Beschreibung:
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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