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K+LINE+LOGISTIS+(USA)+INC
Artikel-Nr:
(PRSI90-394)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-394
Lokale Artikelnummer::
PRSI90-394
Beschreibung:
CD40 is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain and is expressed in B cells, dendritic cells, macrophages, endothelial cells and several tumour cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-kappaB, Jun N-terminal kinase and Janus kinase signal transducers and activators of transcription pathways. Several different TRAF proteins (adapter proteins) have been identified to serve as mediators of the signal transduction. In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation and thus is thought to be an early event in Alzheimer disease pathogenesis. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterised by the inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response and a lack of germinal center formation.
VE:
1 * 100 µG
Artikel-Nr:
(PRSIXP-5162BT)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XP-5162BT
Lokale Artikelnummer::
PRSIXP-5162BT
Beschreibung:
Interleukins (ILs) are a large group of cytokines that are produced mainly by leukocytes, although some are produced by certain phagocytes and auxiliary cells. ILs have a variety of functions, but most function to direct other immune cells to divide and differentiate. Each IL acts on a specific, limited group of cells through a receptor specific for that IL. Human IL10 is a non glycosylated polypeptide consisting of 178 amino acids. There is 73% homology between the human and mouse IL10 proteins, however, the human IL10 acts on both human and mouse target cells, while the mouse IL10 has species specific activity. The cellular sources of IL10 are CD4+ T cells and T cell clones, thymocytes, B cells and B cell lymphomas, macrophages, mast cell lines and keratinocytes. IL10 will stimulate the growth of stem cells, mast cells and thymocytes. IL10 enhances cytotoxic T cell development, and costimulates B cell differentiation and immunoglobulin secretion. IL10 inhibits cytokine production by macrophages and suppresses macrophage class II MHC expression. The human IL10 gene is on human chromosome 1.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI49-313)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
49-313
Lokale Artikelnummer::
PRSI49-313
Beschreibung:
Principal Names: SnoN; SNO; SKI-like; Ski-related Oncogene; SnoA; SKIL Official Gene Symbol- SKIL Gen Bank Accession Number- NP_005405 Gene ID- 6498(Human) 20482 (mouse)Gene Map Locus- 3q26 (human) SnoN, an 80 kDa protein, is a member of ski family of nuclear proto-oncogenes involved in regulation of cellular transformation and differentiation. Primarily expressed in two isoforms, SnoN is localized in cytoplasm in normal tissues and non-tumorigenic primary epithelial cells. In cancer tissues or cells, SnoN is exclusively localized in the nucleus. It plays a vital role in inhibition of cell cycle arrest induced by TGF-. Upon morphological differentiation or cell-cycle arrest, SnoN translocates into the nucleus, binds to Smad2, Smad3, and Smad4 on TGF- -responsive promoters and represses their ability to activate expression of TGF- target genes. It has also been found to mediate transcriptional repression of thyroid hormone receptor, Mad and pRb. Increased expression of SnoN has been detected in many human tumor cell lines suggesting a clinical significance.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI50-210)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
50-210
Lokale Artikelnummer::
PRSI50-210
Beschreibung:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
VE:
1 * 100 µl
Artikel-Nr:
(PRSI30-283)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-283
Lokale Artikelnummer::
PRSI30-283
Beschreibung:
FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-5957R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5957R-A680
Lokale Artikelnummer::
BOSSBS-5957R-A680
Beschreibung:
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6295R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6295R-A350
Lokale Artikelnummer::
BOSSBS-6295R-A350
Beschreibung:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6295R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6295R
Lokale Artikelnummer::
BOSSBS-6295R
Beschreibung:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9211R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9211R-CY7
Lokale Artikelnummer::
BOSSBS-9211R-CY7
Beschreibung:
SERPINB10 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in human bone marrow in a search for serpins similar to SerpinB6. SERPINB10 was identified in lymphocytes, and was elevated in chronic myeloid leukemia and chronic myelomonocytic leukemia cells. The monocytic cell lines THP-1 and AML-193 also showed elevated SERPINB10 expression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6114R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6114R-A350
Lokale Artikelnummer::
BOSSBS-6114R-A350
Beschreibung:
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6114R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6114R-FITC
Lokale Artikelnummer::
BOSSBS-6114R-FITC
Beschreibung:
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6114R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6114R-A488
Lokale Artikelnummer::
BOSSBS-6114R-A488
Beschreibung:
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6114R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6114R-A555
Lokale Artikelnummer::
BOSSBS-6114R-A555
Beschreibung:
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5957R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5957R-FITC
Lokale Artikelnummer::
BOSSBS-5957R-FITC
Beschreibung:
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6295R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6295R-A750
Lokale Artikelnummer::
BOSSBS-6295R-A750
Beschreibung:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6295R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6295R-HRP
Lokale Artikelnummer::
BOSSBS-6295R-HRP
Beschreibung:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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