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controlce
Korrigiert: "controlce"
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Artikel-Nr:
(BOSSBS-0252R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0252R-CY3
Lokale Artikelnummer::
BOSSBS-0252R-CY3
Beschreibung:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8443R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8443R-CY5
Lokale Artikelnummer::
BOSSBS-8443R-CY5
Beschreibung:
LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6820R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6820R-CY5
Lokale Artikelnummer::
BOSSBS-6820R-CY5
Beschreibung:
MAGEA5 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI25-728)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-728
Lokale Artikelnummer::
PRSI25-728
Beschreibung:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been found for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-11061R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11061R-A750
Lokale Artikelnummer::
BOSSBS-11061R-A750
Beschreibung:
OLFM3 is a 478 amino acid protein that interacts with myocilin. Myocilin is an extracellular protein that plays a key role in the actomyosin system and is responsible for controlling intraocular pressure. OLFM3 is a secreted protein that contains an olfactomedin-like (OLF) domain, an approximately 260 amino acid motif commonly found in secreted glycoproteins. OLFM3 localizes to the Golgi apparatus of the cell and is highly expressed in both eye and brain tissue. Mutations in the gene that encodes OLFM3 may cause severe glaucoma, a condition in which increased intraocular pressure within the eyeball causes loss of eye sight.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4888R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4888R-A488
Lokale Artikelnummer::
BOSSBS-4888R-A488
Beschreibung:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11754R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11754R-A488
Lokale Artikelnummer::
BOSSBS-11754R-A488
Beschreibung:
SCGN is a 276 amino acid cytoplasmic protein that contains six EF-hand domains and is related to the calicium-binding proteins Calretinin and Calbindin D28K. Expressed in a variety of tissues including stomach, thyroid, colon, brain and neuroendocrine cells, SCGN is thought to be involved in cell proliferation and KCl (potassium chloride)-mediated calcium flux events. Through its interaction with KCl and its subsequent ability to modulate calcium storage pools within the cell, SCGN may function to negatively control growth and differentiation rates and, thus, indirectly inhibit cell replication.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5751R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5751R-A555
Lokale Artikelnummer::
BOSSBS-5751R-A555
Beschreibung:
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. MATK is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6823R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6823R-A680
Lokale Artikelnummer::
BOSSBS-6823R-A680
Beschreibung:
MAGEB3 is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localised in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11754R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11754R-A350
Lokale Artikelnummer::
BOSSBS-11754R-A350
Beschreibung:
SCGN is a 276 amino acid cytoplasmic protein that contains six EF-hand domains and is related to the calicium-binding proteins Calretinin and Calbindin D28K. Expressed in a variety of tissues including stomach, thyroid, colon, brain and neuroendocrine cells, SCGN is thought to be involved in cell proliferation and KCl (potassium chloride)-mediated calcium flux events. Through its interaction with KCl and its subsequent ability to modulate calcium storage pools within the cell, SCGN may function to negatively control growth and differentiation rates and, thus, indirectly inhibit cell replication.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13052R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13052R-HRP
Lokale Artikelnummer::
BOSSBS-13052R-HRP
Beschreibung:
EDD is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7882R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7882R-A350
Lokale Artikelnummer::
BOSSBS-7882R-A350
Beschreibung:
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12580R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12580R-CY3
Lokale Artikelnummer::
BOSSBS-12580R-CY3
Beschreibung:
ARID3B represents a member of a unique family of DNA-binding proteins that have roles in cell lineage gene regulation, cell cycle control, embryonic patterning and transcriptional regulation. ARID3B localizes to the nucleus and contains an AT-rich interactive domain (ARID) which has DNA-binding capabilities. Functioning as a transcription factor, ARID3B associates in a heterodimer with the related protein ARID3A and is believed to play an important role in neural crest survival during embryogenesis. In addition, ARID3B may participate in malignant transformation and neuroblastoma growth, suggesting a possible use of ARID3B as a tumor marker for neuroblastoma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7882R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7882R-A750
Lokale Artikelnummer::
BOSSBS-7882R-A750
Beschreibung:
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0160R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0160R-A647
Lokale Artikelnummer::
BOSSBS-0160R-A647
Beschreibung:
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11262R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11262R-A750
Lokale Artikelnummer::
BOSSBS-11262R-A750
Beschreibung:
MP21 is a member of the EMP24/GP25L/p24 cargo family of proteins that regulates vesicular trafficking in the early secretory pathway. TMP21 is a ubiquitously expressed single-pass type I membrane protein localizing to the Golgi cisternae and the plasma membrane. It contains one GOLD (Golgi dynamics) domain and participates in protein transport and quality control between the endoplasmic reticulum (ER) and the Golgi complex. In addition, TMP21 is a component of the heteromeric secretase complex (or Presenilin complex) and functions to regulate the secretase activity. Two isoforms, namely TMP21-I and TMP21-II, exist for this protein.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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