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Potassium+trifluoro(hex-1-yn-1-yl)borate
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Potassium+trifluoro(hex-1-yn-1-yl)borate
Lieferant:
Cayman Chemical
Beschreibung:
Metamizole (sodium salt) is a nonopioid prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), which have analgesic and antipyretic effects. MAA has been shown to inhibit COX activity 8-9-fold more potently than AA (COX-1: IC<sub>50</sub><sup>S</sup>= 2,6 and 20,8 µM, respectively, and COX-2: IC<sub>50</sub><sup>S</sup>= 4,7 and 41,8 µM, respectively). These metabolites can be further acylated with arachidonic acid to form compounds that can bind to central and peripheral cannabinoid (CB<sub>1</sub> and CB<sub>2</sub>) receptors and TRPV1 receptors at low micromolar concentrations.
Artikel-Nr:
(PRSI92-417)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-417
Lokale Artikelnummer::
PRSI92-417
Beschreibung:
Phospholipase A2(PLA2G1B) is a secreted protein which belongs to the phospholipase A2 family. It catalyses the release of fatty acids from glycero-3-phosphocholines. It catalyses the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Sequences of pancreatic PLA2G1B enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Mice lacking in PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. Oral supplementation of a diabetogenic diet with the PLA2G1B inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
VE:
1 * 50 µG
Lieferant:
VWR Chemicals
Beschreibung:
Alle unsere Nährmedien werden aus hochwertigen Rohstoffen hergestellt und unterliegen strengen Qualitätskontrollen; bei der Produktion kommen die aktuellen Good Manufacturing Practice-Richtlinien (GMP) zur Anwendung. Die Rohstoffe werden entsprechend den erforderlichen Standards ausgewählt. Trockennährmedien sollten, sofern nicht anders angegeben, bei 10 bis 30 °C in ihren verschlossenen Behältern in trockener Umgebung aufbewahrt werden. Eine Reihe an Nährmedien ist gemäß ISO-Normen und der international harmonisierten Pharmakopöe.
Artikel-Nr:
(PRSI91-406)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-406
Lokale Artikelnummer::
PRSI91-406
Beschreibung:
Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. These enzymes have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They are major determinants of the pharmacokinetic behavior of most therapeutic agents containing an ester or amide bond. CES1 shares the serine hydrolase fold observed in other esterases. CES1 hydrolyses aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. CES1 participates in detoxification of drugs such as cocaine and heroin in serum and liver. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI7151)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7151
Lokale Artikelnummer::
PRSI7151
Beschreibung:
MECR Antibody: The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
VE:
1 * 100 µG
Artikel-Nr:
(220271000.)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
220271000
Lokale Artikelnummer::
ACRO220271000
Beschreibung:
Benzoylchlorid 99%, AcroSeal®, rein
VE:
1 * 100 mL
Artikel-Nr:
(PRSI5641)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5641
Lokale Artikelnummer::
PRSI5641
Beschreibung:
ELOVL7 Antibody: Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 7 (ELOVL7) is a member of fatty acyl-CoA elongase gene family that elongates saturated very-long-chain fatty acids (SVLFA, C20:0-) and has been suggested to be involved in prostate cancer growth through saturated long-chain fatty acid metabolism. The metabolic pathways of long-chain fatty acids play an important role in the maintenance of membrane lipid composition and the generation of cell signaling precursor molecules such as eicosanoids and sphingosine-1 phosphate. Overexpression of ELOVL7 results in lipid accumulation in differentiated adipocytes; its expression is regulated by the microRNA miR-219.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-0657R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0657R-CY7
Lokale Artikelnummer::
BOSSBS-0657R-CY7
Beschreibung:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI4939)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4939
Lokale Artikelnummer::
PRSI4939
Beschreibung:
LASS5 Antibody: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-0657R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0657R-CY3
Lokale Artikelnummer::
BOSSBS-0657R-CY3
Beschreibung:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI25-883)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-883
Lokale Artikelnummer::
PRSI25-883
Beschreibung:
ABCD4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-7948R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7948R-CY5
Lokale Artikelnummer::
BOSSBS-7948R-CY5
Beschreibung:
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glyceroN-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0657R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0657R-CY5.5
Lokale Artikelnummer::
BOSSBS-0657R-CY5.5
Beschreibung:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
VE:
1 * 100 µl
Artikel-Nr:
(29208-50MG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
29208-50MG
Lokale Artikelnummer::
SUPL29208-50MG
Beschreibung:
N-Succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium bromide (TMPP-Ac-OSu) is an acylating reagent, and is generally used for the selective derivatization of N-terminal a-amino group of peptide.
VE:
1 * 50 mg
Artikel-Nr:
(BOSSBS-7948R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7948R-HRP
Lokale Artikelnummer::
BOSSBS-7948R-HRP
Beschreibung:
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glyceroN-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7948R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7948R-A647
Lokale Artikelnummer::
BOSSBS-7948R-A647
Beschreibung:
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glyceroN-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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