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4-Iodo-3-hydroxypyridine
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4-Iodo-3-hydroxypyridine
Artikel-Nr:
(BOSSBS-12287R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12287R-A555
Lokale Artikelnummer::
BOSSBS-12287R-A555
Beschreibung:
Microtubules mediate the spatial organization of diverse membrane-trafficking systems. The HOOK proteins, HOOK1, HOOK2 and HOOK3, comprise a family of cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules; and more divergent C-terminal domains, which mediate binding to organelles. HOOK1, a cytoskeletal linker protein, may play a role in endocytic membrane trafficking. It exists as a homodimer, most likely mediated through its central coiled-coil domain. HOOK1 interacts with VPS18 and is required for spermatid differentiation, in which it is most likely involved in the positioning of the manchette microtubules and the flagellum. HOOK1 localizes primarily to the cytoplasm and does not associate with the Golgi complex, unlike HOOK3, which participates in the organization of the cis-Golgi compartment.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3541R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3541R-HRP
Lokale Artikelnummer::
BOSSBS-3541R-HRP
Beschreibung:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Methylenblau Hydrat, rein
Artikel-Nr:
(BOSSBS-8687R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8687R-CY7
Lokale Artikelnummer::
BOSSBS-8687R-CY7
Beschreibung:
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8687R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8687R-CY5
Lokale Artikelnummer::
BOSSBS-8687R-CY5
Beschreibung:
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
VE:
1 * 100 µl
Artikel-Nr:
(SIAL296759-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
296759-1G
Lokale Artikelnummer::
SIAL296759-1G
Beschreibung:
Iodmethan-[D3] (99,9% ¹²C, 98% D) stabilisiert, Sigma-Aldrich®
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-8687R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8687R-CY5.5
Lokale Artikelnummer::
BOSSBS-8687R-CY5.5
Beschreibung:
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8333R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8333R
Lokale Artikelnummer::
BOSSBS-8333R
Beschreibung:
RDH13, also known as all-trans and 9-cis retinol dehydrogenase 13 or SDR7C3, is a 331 amino acid mitochondrial protein belonging to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed, mostly in eye, pancreas, placenta and lung, RDH13 localizes on the outer side of the inner mitochondrial membrane. Related to microsomal retinoid oxidoreductase RDH11, RDH13 is considered to be a major enzyme among the RDH family of proteins. Catalytically active, RDH13 recognizes retinoids as substrates and may function in retinoic acid production. RDH13 may function to protect the mitochondria against oxidative stress. Leber congenital amaurosis (LCA) type 3, an inherited autosomal recessive retinal disease, has been associated with defects of RDH13. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
VE:
1 * 100 µl
Artikel-Nr:
(EHERL16140000CY)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
L16140000CY
Lokale Artikelnummer::
EHERL16140000CY
Beschreibung:
Organic Standard, Phosphamidon (Gemisch der cis- und trans-Isomeren) 10 µg/ml in Cyclohexan, Packung: Glasflasche
VE:
1 * 10 mL
Lieferant:
Sigma-Aldrich
Beschreibung:
1,2-Cyclohexandicarbonsäureanhydrid (Gemisch der cis- und trans-Isomeren), Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-3541R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3541R-CY7
Lokale Artikelnummer::
BOSSBS-3541R-CY7
Beschreibung:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3541R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3541R-CY5
Lokale Artikelnummer::
BOSSBS-3541R-CY5
Beschreibung:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Appearance: Clear light yellow Viscous liquid
Artikel-Nr:
(BOSSBS-2358R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2358R-CY5.5
Lokale Artikelnummer::
BOSSBS-2358R-CY5.5
Beschreibung:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
Dimethylcyclohexan-1,4-dicarboxylat (Gemisch der cis- und trans-Isomeren), Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
1,4-Cyclohexandicarbonsäure (Gemisch der cis- und trans-Isomeren), Sigma-Aldrich®
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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