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4-Bromo-1H-indazole-6-carboxylic acid
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4-Bromo-1H-indazole-6-carboxylic acid
Artikel-Nr:
(BOSSBS-11480R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11480R-A555
Lokale Artikelnummer::
BOSSBS-11480R-A555
Beschreibung:
Semaphorins are a family of cell surface and secreted proteins involved in neural development that are conserved from insects to humans. Members of this family are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin†domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. The transmembrane semaphorins are characterized by an additional 80 amino acid transmembrane domain and an 80-110 amino acid cytoplasmic domain. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA3E is a secreted semaphorin with 775 amino acids. Mutations in the SEMA3E gene are associated with CHARGE syndrome, a disorder characterized by cranial nerve dysfunction, coloboma of the eye, choanal atresia, inner and external ear abnormalities, cardiac anomalies, genitourinary abnormalities, and growth retardation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9960R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9960R-A680
Lokale Artikelnummer::
BOSSBS-9960R-A680
Beschreibung:
Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognised for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. The C19orf29 gene product has been provisionally designated C19orf29 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11480R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11480R-A488
Lokale Artikelnummer::
BOSSBS-11480R-A488
Beschreibung:
Semaphorins are a family of cell surface and secreted proteins involved in neural development that are conserved from insects to humans. Members of this family are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin†domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. The transmembrane semaphorins are characterized by an additional 80 amino acid transmembrane domain and an 80-110 amino acid cytoplasmic domain. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA3E is a secreted semaphorin with 775 amino acids. Mutations in the SEMA3E gene are associated with CHARGE syndrome, a disorder characterized by cranial nerve dysfunction, coloboma of the eye, choanal atresia, inner and external ear abnormalities, cardiac anomalies, genitourinary abnormalities, and growth retardation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9740R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9740R-CY5
Lokale Artikelnummer::
BOSSBS-9740R-CY5
Beschreibung:
CNTD2 (cyclin N-terminal domain containing 2) is a 155 amino acid protein that contains one cyclin N-terminal domain and is encoded by a gene that maps to human chromosome 19q13.2. Chromosome 19 consists of approximately 63 million bases and makes up over 2% of human genomic DNA. Chromosome 19 is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members, including killer cell and leukocyte Ig-like receptors, various ICAMs, the CEACAM and PSG families, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene Bcl-3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6578R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6578R-A488
Lokale Artikelnummer::
BOSSBS-6578R-A488
Beschreibung:
The sterile alpha motif (SAM) domain is a 70 residue structure found in a large number of proteins involved in diverse processes present throughout eukaryotes. The SAM domain is known to bind RNA and is arranged in a small five-helix bundle with two large interfaces. SAMD14 (sterile alpha motif domain-containing protein 14) is a 417 amino acid protein encoded by the SAMD14 gene which maps to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth, Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease.
VE:
1 * 100 µl
Artikel-Nr:
(PROOCIL-PCB-159)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
CIL-PCB-159
Lokale Artikelnummer::
PROOCIL-PCB-159
Beschreibung:
Organic Standard, 2,3,3',4,5,5'-Hexachlorbiphenyl (PCB Nr. 159) 35 µg/ml in Isooctan, Packung: Glasflasche
VE:
1 * 1 mL
Artikel-Nr:
(BOSSBS-9084R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9084R-FITC
Lokale Artikelnummer::
BOSSBS-9084R-FITC
Beschreibung:
Belonging to the F-box family of proteins, FBXO35 (F-box only protein 35), also designated F-box and WD-40 domain-containing protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously expressed at low levels in most human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13472R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13472R-FITC
Lokale Artikelnummer::
BOSSBS-13472R-FITC
Beschreibung:
GTPases from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein Rpl25a to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. GNL3L (guanine nucleotide binding protein-like 3 (nucleolar)-like) is a 582 amino acid nuclear protein that belongs to the MMR1/HSR1 GTP-binding protein family. Containing one G (guanine nucleotide-binding) domain, GNL3L is required for normal processing of ribosomal pre-rRNA and for cell proliferation.
VE:
1 * 100 µl
Lieferant:
OHAUS
Beschreibung:
Stativ-Set, 35 cm, Edelstahl
Artikel-Nr:
(AGRIAS08317)
Lieferant:
Agrisera
Hersteller-Artikelnummer::
AS08317
Lokale Artikelnummer::
AGRIAS08317
Beschreibung:
Anti-14-3-3C Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11483R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11483R-A647
Lokale Artikelnummer::
BOSSBS-11483R-A647
Beschreibung:
Semaphorins are a family of cell surface and secreted proteins involved in neural development that are conserved from insects to humans. Members of this family are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin†domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. The transmembrane semaphorins are characterized by an additional 80 amino acid transmembrane domain and an 80-110 amino acid cytoplasmic domain. SEMA6C, also known as SEMA Y, is a transmembrane protein expressed in fetal brain and adult skeletal muscle. Three isoforms of this semaphorin exist due to alternative splicing: SEMA6C 1, SEMA6C 2 and SEMA6C 3. The extracellular domain of SEMA6C induces growth cone collapse of dorsal root ganglion and plays a role in generation or stability of entorhino-hippocampal synapses.
VE:
1 * 100 µl
Artikel-Nr:
(USBIC0107-02B)
Lieferant:
US Biological
Hersteller-Artikelnummer::
C0107-02B
Lokale Artikelnummer::
USBIC0107-02B
Beschreibung:
Anti-CDH15 Sheep Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(KRAF20047.5020)
Lieferant:
Bernd Kraft
Hersteller-Artikelnummer::
20047.5020
Lokale Artikelnummer::
KRAF20047.5020
Beschreibung:
Natriumhydroxid-Lösung 35% zur Analyse
VE:
1 * 5 L
Artikel-Nr:
(PROOCIL-PCB-109)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
CIL-PCB-109
Lokale Artikelnummer::
PROOCIL-PCB-109
Beschreibung:
Organic Standard, 2,3,3',4,6-Pentachlorbiphenyl (PCB Nr. 109) 35 µg/ml in Isooctan, Packung: Glasflasche
VE:
1 * 1 mL
Artikel-Nr:
(BOSSBS-2562R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2562R-A647
Lokale Artikelnummer::
BOSSBS-2562R-A647
Beschreibung:
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5216R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5216R-CY5.5
Lokale Artikelnummer::
BOSSBS-5216R-CY5.5
Beschreibung:
Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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