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N-Boc-D-serine+methyl+ester
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N-Boc-D-serine+methyl+ester
Artikel-Nr:
(BOSSBS-10501R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10501R-HRP
Lokale Artikelnummer::
BOSSBS-10501R-HRP
Beschreibung:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1967R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1967R-A680
Lokale Artikelnummer::
BOSSBS-1967R-A680
Beschreibung:
Kallikrein 9, also known as Kallikrein-Like 3 (KLK-L3), is a chymotrypsin-like serine proteinase. Kallikrein 9 was discovered as the locus for kallikreins on chromosome 19 was more fully mapped and found by similarity to the other tissue kallikreins. Kallikrein 9 has been found in the ovary, thymus, testis, prostate, skin, breast and neuronal tissues and is made by many cell lines in culture. Kallikrein 9 levels in breast cancer and uterine cancer patients have been reported to drop as the disease progresses, thus hK9 might be considered a favorable prognostic marker. Different splice variants of hK9 have been reported, although it is not yet known if they produce functional proteins. The full length Kallikrein 9 encodes for a 250 amino acid protein, with a predicted mass of 27.5 kDa and a pI of 7.53. The 234 amino acid form predicts a protein of 26 kDa with a pI of 9.76 and this quite basic pI might give the shorter form a very different function or localisation. The shorter sequence also diverges before the catalytic serine residue, making it unlikely to be proteolytically active. Pre-pro-kallikrein 9 has the 17 amino acid signal sequence is removed before secretion, and the Pro-kallikrein 9 is activated to Kallikrein 9 by removal of the 5 amino acid propeptide domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3232R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3232R-CY3
Lokale Artikelnummer::
BOSSBS-3232R-CY3
Beschreibung:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3232R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3232R-A488
Lokale Artikelnummer::
BOSSBS-3232R-A488
Beschreibung:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3232R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3232R-FITC
Lokale Artikelnummer::
BOSSBS-3232R-FITC
Beschreibung:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
VE:
1 * 100 µl
Artikel-Nr:
(USBIM4676-02N-AP)
Lieferant:
US Biological
Hersteller-Artikelnummer::
M4676-02N-AP
Lokale Artikelnummer::
USBIM4676-02N-AP
Beschreibung:
Anti-MOS Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))
VE:
1 * 200 µl
Artikel-Nr:
(USBI040171-FITC)
Lieferant:
US Biological
Hersteller-Artikelnummer::
040171-FITC
Lokale Artikelnummer::
USBI040171-FITC
Beschreibung:
Anti-PLK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
VE:
1 * 200 µl
Artikel-Nr:
(USBI131195)
Lieferant:
US Biological
Hersteller-Artikelnummer::
131195
Lokale Artikelnummer::
USBI131195
Beschreibung:
Anti-CDK15 Mouse Polyclonal Antibody
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-5275R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5275R-HRP
Lokale Artikelnummer::
BOSSBS-5275R-HRP
Beschreibung:
Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
VE:
1 * 100 µl
Lieferant:
BACHEM BIOCHEMICA
Beschreibung:
L(+)-Serin
Artikel-Nr:
(BOSSBS-7685R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7685R-CY5.5
Lokale Artikelnummer::
BOSSBS-7685R-CY5.5
Beschreibung:
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared to isoform 1.
VE:
1 * 100 µl
Lieferant:
BACHEM BIOCHEMICA
Beschreibung:
D(-)-Serin
Artikel-Nr:
(BOSSBS-3756R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3756R
Lokale Artikelnummer::
BOSSBS-3756R
Beschreibung:
PPP1A is a serine/threonine protein phosphatase catalytic subunit that is essential for regulating cellular stress responses in eukaryotes. It binds to magnesium or manganese ions and exists as a monomer. It is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1A is involved in the regulation long term synaptic plasticity and may play an important role in dephosphorylating substrates such as Ca2+/calmodulin dependent protein kinase II.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5275R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5275R-CY5
Lokale Artikelnummer::
BOSSBS-5275R-CY5
Beschreibung:
Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
VE:
1 * 100 µl
Artikel-Nr:
(USBI135392)
Lieferant:
US Biological
Hersteller-Artikelnummer::
135392
Lokale Artikelnummer::
USBI135392
Beschreibung:
Anti-WNK4 Mouse Monoclonal Antibody [clone: 1E6]
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-10501R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10501R-A555
Lokale Artikelnummer::
BOSSBS-10501R-A555
Beschreibung:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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