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cis-6-Amino-cyclohex-3-enecarboxylic+acid
Artikel-Nr:
(BOSSBS-1135R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-A647
Lokale Artikelnummer::
BOSSBS-1135R-A647
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1135R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-CY5.5
Lokale Artikelnummer::
BOSSBS-1135R-CY5.5
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(C5548-100MG)
Lieferant:
SIGMA ALDRICH MICROSCOPY
Hersteller-Artikelnummer::
C5548-100MG
Lokale Artikelnummer::
SIAMC5548-100MG
Beschreibung:
Clobetasone butyrate is a corticosteroid. It can be used as a diagnostic assay manufacturing, hematology, histology. Clobetasone butyrate has been used as an internal standard for the quantitative assay of clobetasol propionate. Clobetasone butyrate has been used to analyse its bio-concentration factor (BCF) in cyprinus carpio. Clobetasone butyrate is a potent topical corticosteroid and is primarily used to treat atopic dermatitis (AD). Low dosage of this drug is used to treat dry eye in sjogrens syndrome.
VE:
1 * 100 mg
Lieferant:
Alfa Aesar
Beschreibung:
5-Chloranthranilsäure 98%
Artikel-Nr:
(90-1004-84)
Lieferant:
Cytiva
Hersteller-Artikelnummer::
90-1004-84
Lokale Artikelnummer::
GEHE90-1004-84
Beschreibung:
Streptavidin Sepharose™ High Performance is an affinity chromatography resin designed for fast and reliable, high resolution purification of biotinylated biomolecules.
VE:
1 * 25 mL
Artikel-Nr:
(BOSSBS-2735R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2735R-CY5.5
Lokale Artikelnummer::
BOSSBS-2735R-CY5.5
Beschreibung:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD160492-5G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD160492-5G
Lokale Artikelnummer::
BLDPBD160492-5G
Beschreibung:
Ethyl-2-chlorothiazole-4-carboxylate 95%
VE:
1 * 5 g
Artikel-Nr:
(BLDPBD159399-25G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD159399-25G
Lokale Artikelnummer::
BLDPBD159399-25G
Beschreibung:
Methyl-2-chlorooxazole-4-carboxylate 98%
VE:
1 * 25 g
Lieferant:
Spectrum Chemical
Beschreibung:
Ascorbyl Palmitate, NF is often used to promote flow of tableting powders and to prevent their sticking in tablet presses.
Lieferant:
COMBI-BLOCKS
Beschreibung:
Methyl-4-brom-2-methoxybenzoat
Lieferant:
Avantor
Beschreibung:
Kaliumacetat ≥99,0%, Kristalle, BAKER ANALYZED® ACS, J.T.Baker®
Artikel-Nr:
(BLDPBD217050-250MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD217050-250MG
Lokale Artikelnummer::
BLDPBD217050-250MG
Beschreibung:
Methyl-2-chlorothiazole-5-carboxylate 95%
VE:
1 * 250 mg
Lieferant:
Sigma-Aldrich
Beschreibung:
Adenosin-5'-triphosphat Dinatriumsalz (ATP Dinatriumsalz) Hydrat, Sigma-Aldrich®
Lieferant:
Cytiva
Beschreibung:
Superdex prep grade (pg) is produced by covalent bonding of dextran to highly cross-linked agarose.The separation properties of these media are determined by the dextran component
Lieferant:
FLUOROCHEM
Beschreibung:
(±)-3-Chinuclidinol
Artikel-Nr:
(HONCR1644-100MG)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
R1644-100MG
Lokale Artikelnummer::
HONCR1644-100MG
Beschreibung:
High quality organic reference materials produced according to ISO 9001.
VE:
1 * 100 mg
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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