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Plant+Learning+Activities
Artikel-Nr:
(BOSSBS-0074R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0074R-HRP
Lokale Artikelnummer::
BOSSBS-0074R-HRP
Beschreibung:
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P1, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2639R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2639R-CY5
Lokale Artikelnummer::
BOSSBS-2639R-CY5
Beschreibung:
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2639R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2639R-CY5.5
Lokale Artikelnummer::
BOSSBS-2639R-CY5.5
Beschreibung:
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8161R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8161R-A750
Lokale Artikelnummer::
BOSSBS-8161R-A750
Beschreibung:
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalisation to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.Tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0984R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0984R-CY5
Lokale Artikelnummer::
BOSSBS-0984R-CY5
Beschreibung:
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5799R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5799R-CY3
Lokale Artikelnummer::
BOSSBS-5799R-CY3
Beschreibung:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2739R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2739R-A350
Lokale Artikelnummer::
BOSSBS-2739R-A350
Beschreibung:
PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5537R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5537R-A488
Lokale Artikelnummer::
BOSSBS-5537R-A488
Beschreibung:
PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12513R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12513R-CY3
Lokale Artikelnummer::
BOSSBS-12513R-CY3
Beschreibung:
ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), ARFGAP2 (ADP-ribosylation factor GTPase-activating protein 2) and ARFGAP3 (ADP-ribosylation factor GTPase-activating protein 3) are GTPase-activating proteins (GAP) that are associated with the Golgi apparatus and interact with ADP-ribosylation factor 1 (ARF). These proteins promote hydrolysis of ARF-bound GTP and are required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of ARFGAP1, ARFGAP2 and ARFGAP3 is stimulated by phosphoinosides and inhibited by phosphatidylcholine. The genes encoding ARFGAP1, ARFGAP2 and ARFGAP3 map to human chromosomes 20q13.33, 11p11.2 and 22q13.2, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11058R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11058R
Lokale Artikelnummer::
BOSSBS-11058R
Beschreibung:
May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3160R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3160R-CY7
Lokale Artikelnummer::
BOSSBS-3160R-CY7
Beschreibung:
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0058R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0058R-CY5.5
Lokale Artikelnummer::
BOSSBS-0058R-CY5.5
Beschreibung:
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0058R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0058R-CY5
Lokale Artikelnummer::
BOSSBS-0058R-CY5
Beschreibung:
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0058R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0058R-CY7
Lokale Artikelnummer::
BOSSBS-0058R-CY7
Beschreibung:
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9047R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9047R-CY7
Lokale Artikelnummer::
BOSSBS-9047R-CY7
Beschreibung:
Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0118R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0118R-A488
Lokale Artikelnummer::
BOSSBS-0118R-A488
Beschreibung:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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