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Plant+Learning+Activities
Artikel-Nr:
(BOSSBS-9079R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9079R-A350
Lokale Artikelnummer::
BOSSBS-9079R-A350
Beschreibung:
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5164R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5164R-A488
Lokale Artikelnummer::
BOSSBS-5164R-A488
Beschreibung:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6411R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6411R-A750
Lokale Artikelnummer::
BOSSBS-6411R-A750
Beschreibung:
CDK5 (Cyclin Dependent Kinase 5) is serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression. CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5164R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5164R-A350
Lokale Artikelnummer::
BOSSBS-5164R-A350
Beschreibung:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5164R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5164R-A750
Lokale Artikelnummer::
BOSSBS-5164R-A750
Beschreibung:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. catalyses the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. hydrolyses 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0792R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0792R-CY5
Lokale Artikelnummer::
BOSSBS-0792R-CY5
Beschreibung:
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0792R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0792R-CY3
Lokale Artikelnummer::
BOSSBS-0792R-CY3
Beschreibung:
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11527R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11527R-CY5
Lokale Artikelnummer::
BOSSBS-11527R-CY5
Beschreibung:
Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5437R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5437R-A350
Lokale Artikelnummer::
BOSSBS-5437R-A350
Beschreibung:
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5437R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5437R-A555
Lokale Artikelnummer::
BOSSBS-5437R-A555
Beschreibung:
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5437R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5437R-A488
Lokale Artikelnummer::
BOSSBS-5437R-A488
Beschreibung:
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11874R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11874R
Lokale Artikelnummer::
BOSSBS-11874R
Beschreibung:
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T cells signaling pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3447R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3447R-CY5
Lokale Artikelnummer::
BOSSBS-3447R-CY5
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1778R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1778R-A680
Lokale Artikelnummer::
BOSSBS-1778R-A680
Beschreibung:
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0163R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0163R-CY5
Lokale Artikelnummer::
BOSSBS-0163R-CY5
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0163R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0163R-CY3
Lokale Artikelnummer::
BOSSBS-0163R-CY3
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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