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Plant+Learning+Activities
Artikel-Nr:
(BOSSBS-0481R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0481R-HRP
Lokale Artikelnummer::
BOSSBS-0481R-HRP
Beschreibung:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0481R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0481R-FITC
Lokale Artikelnummer::
BOSSBS-0481R-FITC
Beschreibung:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0591R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0591R
Lokale Artikelnummer::
BOSSBS-0591R
Beschreibung:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0591R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0591R-A680
Lokale Artikelnummer::
BOSSBS-0591R-A680
Beschreibung:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1860R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1860R-CY3
Lokale Artikelnummer::
BOSSBS-1860R-CY3
Beschreibung:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4202R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4202R
Lokale Artikelnummer::
BOSSBS-4202R
Beschreibung:
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9456R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9456R-CY3
Lokale Artikelnummer::
BOSSBS-9456R-CY3
Beschreibung:
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1178R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1178R-A680
Lokale Artikelnummer::
BOSSBS-1178R-A680
Beschreibung:
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12420R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12420R-A680
Lokale Artikelnummer::
BOSSBS-12420R-A680
Beschreibung:
14-3-3 are activates tyrosine and tryptophan hydroxylases in the presence of Ca²⁺/calmodulin-dependent protein kinase II, and strongly activates protein kinase C. Is probably a multifunctional regulator of the cell Signalling processes mediated by both kinases. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. 14-3-3 proteins are localised in neurons, and are axonally transported to the nerve terminals. They may be also present, at lower levels, in various other eukaryotic tissues. It belongs to the 14-3-3 family. This antibody is reactive with 14-3-3 Alpha/Beta/Gamma/Delta/Epsilon.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6127R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6127R-A647
Lokale Artikelnummer::
BOSSBS-6127R-A647
Beschreibung:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0181R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0181R-A680
Lokale Artikelnummer::
BOSSBS-0181R-A680
Beschreibung:
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1723R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1723R-CY3
Lokale Artikelnummer::
BOSSBS-1723R-CY3
Beschreibung:
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1723R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1723R-FITC
Lokale Artikelnummer::
BOSSBS-1723R-FITC
Beschreibung:
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3693R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3693R-CY5.5
Lokale Artikelnummer::
BOSSBS-3693R-CY5.5
Beschreibung:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1478R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1478R-A488
Lokale Artikelnummer::
BOSSBS-1478R-A488
Beschreibung:
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1478R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1478R-A555
Lokale Artikelnummer::
BOSSBS-1478R-A555
Beschreibung:
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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