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Plant+Learning+Activities
Artikel-Nr:
(BOSSBS-6536R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6536R-A488
Lokale Artikelnummer::
BOSSBS-6536R-A488
Beschreibung:
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6536R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6536R-A350
Lokale Artikelnummer::
BOSSBS-6536R-A350
Beschreibung:
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6536R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6536R-HRP
Lokale Artikelnummer::
BOSSBS-6536R-HRP
Beschreibung:
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2680R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2680R-A680
Lokale Artikelnummer::
BOSSBS-2680R-A680
Beschreibung:
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6162R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6162R-CY3
Lokale Artikelnummer::
BOSSBS-6162R-CY3
Beschreibung:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for normal cytokinesis and cilia signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1077R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1077R-A488
Lokale Artikelnummer::
BOSSBS-1077R-A488
Beschreibung:
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform OCT2.5 activates the U2 small nuclear RNA (snRNA) promoter. Isoforms OCT2.1, OCT2.2 and OCT2.3 activate octamer-containing promoters. Isoforms OCT2.4 and OCT2.5 repress some promoters and activate others. Isoform OCT2.7 is unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1077R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1077R
Lokale Artikelnummer::
BOSSBS-1077R
Beschreibung:
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform OCT2.5 activates the U2 small nuclear RNA (snRNA) promoter. Isoforms OCT2.1, OCT2.2 and OCT2.3 activate octamer-containing promoters. Isoforms OCT2.4 and OCT2.5 repress some promoters and activate others. Isoform OCT2.7 is unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3387R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3387R
Lokale Artikelnummer::
BOSSBS-3387R
Beschreibung:
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6864R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6864R-CY5.5
Lokale Artikelnummer::
BOSSBS-6864R-CY5.5
Beschreibung:
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0480R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0480R-CY3
Lokale Artikelnummer::
BOSSBS-0480R-CY3
Beschreibung:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0481R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0481R-CY7
Lokale Artikelnummer::
BOSSBS-0481R-CY7
Beschreibung:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0984R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0984R-A350
Lokale Artikelnummer::
BOSSBS-0984R-A350
Beschreibung:
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13308R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13308R-A555
Lokale Artikelnummer::
BOSSBS-13308R-A555
Beschreibung:
The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating proteins (GCAP). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily and are specifically expressed in retina. GCAP3 (Guanylyl cyclase-activating protein 3), also known as GUCA1C (Guanylate cyclase activator 1C), is a 209 amino acid EF-hand calcium binding protein that is activated by the decrease in calcium from the absorption of light by rhodopsin. Activation of GCAP3 leads to stimulation of guanylate cyclase 1 and 2 (GC1 and GC2), which increases cGMP concentration. Calcium sensitive regulation of GC is essential in recovery of the rod receptor dark state following light exposure. There are two isoforms of GCAP3 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3016R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3016R-A488
Lokale Artikelnummer::
BOSSBS-3016R-A488
Beschreibung:
p44/42 MAP Kinase(Thr202); ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6098R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6098R-CY5.5
Lokale Artikelnummer::
BOSSBS-6098R-CY5.5
Beschreibung:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2646R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2646R-CY5.5
Lokale Artikelnummer::
BOSSBS-2646R-CY5.5
Beschreibung:
Lymphocyte-activation protein 3 (LAG-3), also known as CD223, belongs to the immunoglobulin superfamily and contains 4 extracellular Ig-like domains. LAG-3 binds to HLA class-II antigens and is involved in lymphocyte activation. It is found on the cell surface of activated NK and T-lymphocytes. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG-3 to CD4.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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