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Plant+Learning+Activities
Artikel-Nr:
(USBIA1475-08E)
Lieferant:
US Biological
Hersteller-Artikelnummer::
A1475-08E
Lokale Artikelnummer::
USBIA1475-08E
Beschreibung:
Anti-AMP Activated Protein Kinase 1, 2 Rabbit Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-10425R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10425R-HRP
Lokale Artikelnummer::
BOSSBS-10425R-HRP
Beschreibung:
Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
VE:
1 * 100 µl
Lieferant:
SIGMA ALDRICH MICROSCOPY
Beschreibung:
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺ -activated protease that is activated during apoptosis.
Artikel-Nr:
(USBI142291-100)
Lieferant:
US Biological
Hersteller-Artikelnummer::
142291-100
Lokale Artikelnummer::
USBI142291-100
Beschreibung:
Anti-Signal Transducer And Activator Of Transcription 3 Rabbit Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(USBIS8025-90D)
Lieferant:
US Biological
Hersteller-Artikelnummer::
S8025-90D
Lokale Artikelnummer::
USBIS8025-90D
Beschreibung:
Anti-SUMO-activating Enzyme Subunit 2 Rabbit Polyclonal Antibody
VE:
1 * 200 µl
Lieferant:
Thermo Scientific
Beschreibung:
Aktivkohle, NORIT® SA 2
Artikel-Nr:
(USBIP4256-31C1)
Lieferant:
US Biological
Hersteller-Artikelnummer::
P4256-31C1
Lokale Artikelnummer::
USBIP4256-31C1
Beschreibung:
Anti-Plasminogen Activator Inhibitor Type 1, inhibitory Mouse Monoclonal Antibody [clone: MA-33H1F7]
VE:
1 * 100 µG
Artikel-Nr:
(86R-1KT)
Lieferant:
SIGMA ALDRICH MICROSCOPY
Hersteller-Artikelnummer::
86R-1KT
Lokale Artikelnummer::
SIAM86R-1KT
Beschreibung:
Leukocyte Alkaline Phosphatase (LAP) kits are intended for the semi-quantitative demonstration of alkaline phosphatase activity in white blood cells.
VE:
1 * 1 KIT
Artikel-Nr:
(BOSSBS-4985R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A750
Lokale Artikelnummer::
BOSSBS-4985R-A750
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-HRP
Lokale Artikelnummer::
BOSSBS-4985R-HRP
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Aktivkohle, Schnecke 6-8 mesh
Artikel-Nr:
(USBIT5600-10G)
Lieferant:
US Biological
Hersteller-Artikelnummer::
T5600-10G
Lokale Artikelnummer::
USBIT5600-10G
Beschreibung:
Anti-Tissue Plasminogen Activator Rabbit Polyclonal Antibody
VE:
1 * 200 µG
Artikel-Nr:
(ABCAAB5620-100)
Lieferant:
Abcam
Hersteller-Artikelnummer::
AB5620-100
Lokale Artikelnummer::
ABCAAB5620-100
Beschreibung:
Anti-Proteasome Activator Subunit 4 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
 This is a MarketSource item. Additional charges may apply
Lieferant:
Alfa Aesar
Beschreibung:
Aktivkohle -20+40 mesh
Artikel-Nr:
(THARJC690-23)
Lieferant:
THARMAC GmbH
Hersteller-Artikelnummer::
JC690-23
Lokale Artikelnummer::
THARJC690-23
Beschreibung:
Fume hood with activated charcoal filter, Cellstain®
VE:
Lieferant:
Thermo Scientific
Beschreibung:
Aktivkohle, NORIT® SA 2, bleichend
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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